At the Root: Defining and Halting Progression of Early Chronic Obstructive Pulmonary Disease

被引：203

作者：

Martinez, Fernando J. ^{[1
,2
]}

Han, MeiLan K. ^{[2
]}

Allinson, James P. ^{[3
]}

Barr, R. Graham ^{[4
]}

Boucher, Richard C. ^{[5
]}

Calverley, Peter M. A. ^{[6
]}

Celli, Bartolome R. ^{[7
]}

Christenson, Stephanie A. ^{[8
]}

Crystal, Ronald G. ^{[1
]}

Fageradegras, Malin ^{[9
]}

Freeman, Christine M. ^{[2
,10
]}

Groenke, Lars ^{[11
]}

Hoffman, Eric A. ^{[12
]}

Kesimer, Mehmet ^{[5
]}

Kostikas, Kostantinos ^{[13
]}

Paine, Robert, III ^{[14
,15
]}

Rafii, Shahin ^{[1
]}

Rennard, Stephen I. ^{[11
]}

Segal, Leopoldo N. ^{[16
]}

Shaykhiev, Renat ^{[1
]}

Stevenson, Christopher ^{[17
]}

Tal-Singer, Ruth ^{[18
]}

Vestbo, Jorgen ^{[19
]}

Woodruff, Prescott G. ^{[8
]}

Curtis, Jeffrey L. ^{[2
,10
]}

Wedzicha, Jadwiga A. ^{[3
]}

机构：

[1] Weill Cornell Med Coll, New York, NY USA

[2] Univ Michigan, Sch Med, Ann Arbor, MI 48109 USA

[3] Imperial Coll, London, England

[4] Columbia Univ, New York, NY USA

[5] Univ N Carolina, Chapel Hill, NC 27515 USA

[6] Sch Clin Sci, Liverpool, Merseyside, England

[7] Harvard Sch Med, Boston, MA USA

[8] Univ Calif San Francisco, San Francisco, CA 94143 USA

[9] AstraZeneca Corp, London, England

[10] Vet Affairs Ann Arbor Healthcare Syst, Ann Arbor, MI USA

[11] Boehringer Ingelheim GmbH & Co KG, Ingelheim, Germany

[12] Univ Iowa, Carver Coll Med, Iowa City, IA USA

[13] Novartis Pharmaceut, Basel, Switzerland

[14] Univ Utah, Salt Lake City, UT USA

[15] Vet Affairs Salt Lake City Hlth Care Syst, Salt Lake City, UT USA

[16] NYU, New York, NY USA

[17] Janssen Pharmaceut, Beerse, Belgium

[18] GlaxoSmithKline, King Of Prussia, PA USA

[19] Odense Univ Hosp, Odense, Denmark

来源：

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | 2018年 / 197卷 / 12期

关键词：

FORCED EXPIRATORY VOLUME; CHRONIC MUCUS HYPERSECRETION; SECRETORY IGA DEFICIENCY; SMALL-AIRWAY-OBSTRUCTION; SURFACE LIQUID VOLUME; LUNG-FUNCTION DECLINE; 1 2ND DECLINE; COMPUTED-TOMOGRAPHY; FEV1; DECLINE; HAEMOPHILUS-INFLUENZAE;

D O I：

10.1164/rccm.201710-2028PP

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

[No abstract available]

引用

页码：1540 / 1551

页数：12

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