Electroencephalography complexity in infantile spasms and its association with treatment response

Objective: To investigate the potential of EEG multiscale entropy and complexity as biomarkers in infantile spasms. Methods: We collected EEG data retrospectively from 16 newly diagnosed patients, 16 ageand gender matched healthy controls, and 15 drug-resistant patients. The multiscale entropy (MSE) and total EEG complexity before anti-epileptic drug (AED) treatment, before adrenocorticotropic hormone (ACTH) treatment, 14 days after ACTH therapy, and after 6 months of follow-up were calculated. Results: The total EEG complexity of 16 newly diagnosed infantile spasms patients was lower than the 16 healthy controls (median [IQR]: 351.5 [323.1-388.1] vs 461.6 [407.7-583.4]). The total EEG complexity before treatment was higher in the six patients with good response to AED than the 10 patients without response (median [IQR]: 410.0 [388.1-475.0] vs 344.5 [319.6-352.0]). The total EEG complexity before and after 14-days of ACTH therapy was not different between 13 ACTH therapy responders and nine non-responders. After 6-months follow-up, the total EEG complexity of ACTH therapy responders were higher than non-responders (median [IQR]: 598.5 [517.4-623.3] vs 448.6 [347.1-536.3]). Conclusions: The total EEG complexity before AED and 6 months after ACTH are associated with spasm-freedom. Significance: The total EEG complexity is a potential biomarker to predict and monitor the treatment effect in infantile spasms. (c) 2021 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.