Electroencephalography complexity in infantile spasms and its association with treatment response

被引：19
作者：
Chu, Yen-Ju [1 ,2 ]
Chang, Chi-Feng [3 ]
Weng, Wen-Chin [2 ,4 ]
Fan, Pi-Chuan [2 ,4 ]
Shieh, Jiann-Shing [5 ,6 ,7 ]
Lee, Wang-Tso [2 ,4 ,8 ]
机构：
[1] Natl Taiwan Univ Hosp, Dept Emergency Med, Taipei, Taiwan
[2] Natl Taiwan Univ, Dept Pediat Neurol, Childrens Hosp, 8 Chung Shan South Rd, Taipei 100, Taiwan
[3] Univ Southern Calif, Dept Biomed Engn, Los Angeles, CA 90007 USA
[4] Natl Taiwan Univ, Dept Pediat, Coll Med, Taipei, Taiwan
[5] Yuan Ze Univ, Dept Mech Engn, Taoyuan, Taiwan
[6] Yuan Ze Univ, Innovat Ctr Biomed & Healthcare Technol, Taoyuan, Taiwan
[7] Yuan Ze Univ, Innovat Ctr Big Data & Digital Convergence, Taoyuan, Taiwan
[8] Natl Taiwan Univ, Grad Inst Brain & Mind Sci, Coll Med, Taipei, Taiwan
来源：
CLINICAL NEUROPHYSIOLOGY | 2021年 / 132卷 / 02期
关键词：
Epilepsy; West syndrome; EEG complexity; Multiscale entropy;
D O I：
10.1016/j.clinph.2020.12.006
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Objective: To investigate the potential of EEG multiscale entropy and complexity as biomarkers in infantile spasms. Methods: We collected EEG data retrospectively from 16 newly diagnosed patients, 16 ageand gender matched healthy controls, and 15 drug-resistant patients. The multiscale entropy (MSE) and total EEG complexity before anti-epileptic drug (AED) treatment, before adrenocorticotropic hormone (ACTH) treatment, 14 days after ACTH therapy, and after 6 months of follow-up were calculated. Results: The total EEG complexity of 16 newly diagnosed infantile spasms patients was lower than the 16 healthy controls (median [IQR]: 351.5 [323.1-388.1] vs 461.6 [407.7-583.4]). The total EEG complexity before treatment was higher in the six patients with good response to AED than the 10 patients without response (median [IQR]: 410.0 [388.1-475.0] vs 344.5 [319.6-352.0]). The total EEG complexity before and after 14-days of ACTH therapy was not different between 13 ACTH therapy responders and nine non-responders. After 6-months follow-up, the total EEG complexity of ACTH therapy responders were higher than non-responders (median [IQR]: 598.5 [517.4-623.3] vs 448.6 [347.1-536.3]). Conclusions: The total EEG complexity before AED and 6 months after ACTH are associated with spasm-freedom. Significance: The total EEG complexity is a potential biomarker to predict and monitor the treatment effect in infantile spasms. (c) 2021 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：480 / 486
页数：7
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