Determination of beta-blocker drugs in pharmaceutical preparations by non-suppressed ion chromatography

被引：19

作者：

Ghanem, R ^{[1
]}

Bello, MA ^{[1
]}

Callejon, M ^{[1
]}

Guiraum, A ^{[1
]}

机构：

[1] UNIV SEVILLE,FAC CHEM,DEPT ANALYT CHEM,E-41012 SEVILLE,SPAIN

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1996年 / 15卷 / 03期

关键词：

beta-blockers; ion chromatography; pharmaceutical preparations;

D O I：

10.1016/S0731-7085(96)01864-X

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A rapid and feasible chromatographic method for determining atenolol, metoprolol, alprenolol, oxprenolol, acebutolol and propranolol by non-suppressed ion chromatography is proposed. The mobile phase consisted of 50 mM nitric acid in an aqueous Solution of 4% (v/v) acetonitrile. Detection limits are in the range 0.1-2.7 mg 1(-1). The method was successfully applied to the determination of beta-blockers in several pharmaceutical formulations.

引用

页码：383 / 388

页数：6