Harnessing Immune Alterations in Neurodegenerative Diseases

被引：31

作者：

Bjorkqvist, Maria ^{[1
]}

Wild, Edward J. ^{[2
]}

Tabrizi, Sarah J. ^{[2
]}

机构：

[1] Lund Univ, Wallenberg Neurosci Ctr, Dept Expt Med Sci, Neuronal Survival Unit, S-22184 Lund, Sweden

[2] UCL, Inst Neurol, Dept Neurodegenerat Dis, London WC1N 3BG, England

来源：

NEURON | 2009年 / 64卷 / 01期

基金：

英国医学研究理事会;

关键词：

HUNTINGTONS-DISEASE; ACTIVATION; PLASMA; TARGET; ONSET;

D O I：

10.1016/j.neuron.2009.09.034

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Immune dysfunction, a well-established feature of neuroinflammatory disease, is increasingly recognized in neurodegenerative conditions. Its role is emerging as an early and active participant in neuropathology. Inflammation could be modified, with disease-slowing effects, by targeted interventions; it is also readily detectible and could serve as a source of valuable biomarkers.

引用

页码：21 / 24

页数：4

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