Predictive Value of Age- and Sex-Specific Nomograms of Global Plaque Burden on Coronary Computed Tomography Angiography for Major Cardiac Events

被引：32

作者：

Naoum, Christopher ^{[1
]}

Berman, Daniel S. ^{[2
]}

Ahmadi, Amir ^{[3
]}

Blanke, Philipp ^{[1
]}

Gransar, Heidi ^{[2
]}

Narula, Jagat ^{[3
]}

Shaw, Leslee J. ^{[4
]}

Kritharides, Leonard ^{[5
,6
]}

Achenbach, Stephan ^{[7
]}

Al-Mallah, Mouaz H. ^{[8
]}

Andreini, Daniele ^{[9
]}

Budoff, Matthew J. ^{[10
]}

Cademartiri, Filippo ^{[11
,12
]}

Callister, Tracy Q. ^{[13
]}

Chang, Hyuk-Jae ^{[14
,15
]}

Chinnaiyan, Kavitha ^{[16
]}

Chow, Benjamin ^{[17
]}

Cury, Ricardo C. ^{[18
]}

DeLago, Augustin ^{[19
]}

Dunning, Allison ^{[20
]}

Feuchtner, Gudrun ^{[21
]}

Hadamitzky, Martin ^{[22
]}

Hausleiter, Joerg ^{[22
]}

Kaufmann, Philipp A. ^{[23
]}

Kim, Yong-Jin ^{[24
]}

Maffei, Erica ^{[11
,12
]}

Marquez, Hugo ^{[25
]}

Pontone, Gianluca ^{[9
]}

Raff, Gilbert ^{[16
]}

Rubinshtein, Ronen ^{[26
]}

Villines, Todd C. ^{[27
,28
]}

Min, James ^{[29
,30
]}

Leipsic, Jonathon ^{[1
]}

机构：

[1] Univ British Columbia, Dept Med & Radiol, Vancouver, BC, Canada

[2] Cedars Sinai Med Ctr, Dept Imaging, Los Angeles, CA 90048 USA

[3] Mt Sinai Hosp Med Ctr, Dept Cardiol, New York, NY USA

[4] Emory Univ, Sch Med, Div Cardiol, Atlanta, GA 30322 USA

[5] Concord Hosp, Dept Cardiol, Sydney, NSW, Australia

[6] Univ Sydney, Sydney, NSW, Australia

[7] Univ Erlangen Nurnberg, Dept Med, Erlangen, Germany

[8] Wayne State Univ, Henry Ford Hosp, Dept Med, Detroit, MI USA

[9] Univ Milan, IRCCS, Ctr Cardiol Monzino, Dept Clin Sci & Community Hlth, Milan, Italy

[10] Harbor Univ Calif Los Angeles Med Ctr, Dept Med, Torrance, CA USA

[11] Giovanni XXIII Hosp, Cardiovasc Imaging Unit, Treviso, Italy

[12] Erasmus MC, Dept Radiol, Rotterdam, Netherlands

[13] Tennessee Heart & Vasc Inst, Hendersonville, NC USA

[14] Yonsei Univ Hlth Syst, Yonsei Univ, Coll Med, Div Cardiol,Severance Cardiovasc Hosp, Seoul, South Korea

[15] Yonsei Univ Hlth Syst, Yonsei Univ, Coll Med, Severance Biomed Sci Inst, Seoul, South Korea

[16] William Beaumont Hosp, Royal Oak, MI 48072 USA

[17] Univ Ottawa, Dept Med & Radiol, Ottawa, ON, Canada

[18] Baptist Cardiac & Vasc Inst, Miami, FL USA

[19] Capitol Cardiol Associates, Albany, NY USA

[20] Duke Clin Res Inst, Durham, NC USA

[21] Med Univ Innsbruck, Dept Radiol, Innsbruck, Austria

[22] Deutsch Herzzentrum Munich, Div Cardiol, Munich, Germany

[23] Univ Hosp, Dept Nucl Med, Zurich, Switzerland

[24] Seoul Natl Univ Hosp, Seoul, South Korea

[25] Curry Cabral Hosp, Dept Surg, Lisbon, Portugal

[26] Technion Israel Inst Technol, Ruth & Bruce Rappaport Sch Med, Lady Davis Carmel Med Ctr, Dept Cardiol, Haifa, Israel

[27] Walter Reed Med Ctr, Dept Med, Washington, DC USA

[28] Walter Reed Med Ctr, Dept Med, New York, NY USA

[29] New York Presbyterian Hosp, Dept Radiol, New York, NY USA

[30] Weill Cornell Med Coll, New York, NY USA

来源：

CIRCULATION-CARDIOVASCULAR IMAGING | 2017年 / 10卷 / 03期

基金：

美国国家卫生研究院;

关键词：

computed tomography angiography; coronary artery disease; coronary angiography; epidemiology; nomograms; ARTERY-DISEASE; PROGNOSTIC VALUE; INTERNATIONAL MULTICENTER; CARDIOVASCULAR RISK; MORTALITY INCIDENCE; CT ANGIOGRAPHY; CALCIUM;

D O I：

10.1161/CIRCIMAGING.116.004896

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background-Age-adjusted coronary artery disease (CAD) burden identified on coronary computed tomography angiography predicts major adverse cardiovascular event (MACE) risk; however, it seldom contributes to clinical decision making because of a lack of nomographic data. We aimed to develop clinically pragmatic age- and sex-specific nomograms of CAD burden using coronary computed tomography angiography and to validate their prognostic use. Methods and Results-Patients prospectively enrolled in phase I of the CONFIRM registry (Coronary CT Angiography Evaluation for Clinical Outcomes) were included (derivation cohort: n=21,132; 46% female) to develop CAD nomograms based on age-sex percentiles of segment involvement score (SIS) at each year of life (40-79 years). The relationship between SIS age-sex percentiles (SIS%) and MACE (all-cause death, myocardial infarction, unstable angina, and late revascularization) was tested in a nonoverlapping validation cohort (phase II, CONFIRM registry; n=3030, 44% female) by stratifying patients into 3 SIS% groups (<= 50th, 51-75th, and >75th) and comparing annualized MACE rates and time to MACE using multivariable Cox proportional hazards models adjusting for Framingham risk and chest pain typicality. Age-sex percentiles were well fitted to second-order polynomial curves (men: R-2=0.86 +/- 0.12; women: R-2=0.86 +/- 0.14). Using the nomograms, there were 1576, 965, and 489 patients, respectively, in the <= 50th, 51-75th, and >75th SIS% groups. Annualized event rates were higher among patients with greater CAD burden (2.1% [95% confidence interval: 1.7%-2.7%], 3.9% [95% confidence interval: 3.0%-5.1%], and 7.2% [95% confidence interval: 5.4%-9.6%] in 50th, 51-75th, and >75th SIS% groups, respectively; P<0.001). Adjusted MACE risk was significantly increased among patients in SIS% groups above the median compared with patients below the median (hazard ratio [95% confidence interval]: 1.9 [1.3-2.8] for 51-75th SIS% group and 3.4 [2.3-5.0] for >75th SIS% group; P<0.01 for both). Conclusions-We have developed clinically pragmatic age- and sex-specific nomograms of CAD prevalence using coronary computed tomography angiography findings. Global plaque burden measured using SIS% is predictive of cardiac events independent of traditional risk assessment.

引用

页数：11

共 35 条

[21] Major Adverse Cardiac Events and the Severity of Coronary Atherosclerosis Assessed by Computed Tomography Coronary Angiography in an Outpatient Population With Suspected or Known Coronary Artery Disease
Aldrovandi, Annachiara
Maffei, Erica
Seitun, Sara
Martini, Chiara
Berti, Elena
Grilli, Roberto
Messalli, Giancarlo
Weustink, Annick C.
Mollet, Nico R.
Nieman, Koen
Ardissino, Diego
de Feyter, Pim J.
Krestin, Gabriel P.
Cademartiri, Filippo
JOURNAL OF THORACIC IMAGING, 2012, 27 (01) : 23 - 28
[22] Age- and sex-related features of atherosclerosis from coronary computed tomography angiography in patients prior to acute coronary syndrome: results fromthe ICONIC study
Conte, Edoardo
Dwivedi, Aeshita
Mushtaq, Saima
Pontone, Gianluca
Lin, Fay Y.
Hollenberg, Emma J.
Lee, Sang-Eun
Bax, Jeroen
Cademartiri, Filippo
Chinnaiyan, Kavitha
Chow, Benjamin J. W.
Cury, Ricardo C.
Feuchtner, Gudrun
Hadamitzky, Martin
Kim, Yong-Jin
Baggiano, Andrea
Leipsic, Jonathon
Maffei, Erica
Marques, Hugo
Plank, Fabian
Raff, Gilbert L.
van Rosendael, Alexander R.
Villines, Todd C.
Weirich, Harald G.
Al'Aref, Subhi J.
Baskaran, Lohendran
Cho, Iksung
Danad, Ibrahim
Han, Donghee
Heo, Ran
Lee, Ji Hyun
Stuijfzand, Wijnand J.
Gransar, Heidi
Lu, Yao
Sung, Ji Min
Park, Hyung-Bok
Al-Mallah, Mouaz H.
Goncalves, Pedro de Araujo
Berman, Daniel S.
Budoff, Matthew J.
Samady, Habib
Shaw, Leslee J.
Stone, Peter H.
Virmani, Renu
Narula, Jagat
Min, James K.
Chang, Hyuk-Jae
Andreini, Daniele
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, 2021, 22 (01) : 24 - 33
[23] Assessing the Predictive Value of Traditional Risk Factors for Coronary Artery Disease Severity and Plaque Morphology on Coronary Computed Tomography Angiography: Individual vs Population
Ahmadi, Amir A.
Chandy, Mark
Rezazadeh, Saman
Heilbron, Brett
Leipsic, Jonathon
Ramanathan, Krishnan
Taylor, Carolyn
CIRCULATION, 2010, 122 (21)
[24] Does Coronary Artery Calcium Scoring Add to the Predictive Value of Coronary Computed Tomography Angiography for Adverse Cardiovascular Events in Low-risk Chest Pain Patients?
Chang, Anna Marie
Le, Jeffrey
Matsuura, Asako C.
Litt, Harold I.
Hollander, Judd E.
ACADEMIC EMERGENCY MEDICINE, 2011, 18 (10) : 1065 - 1071
[25] Prognostic Value of Computed Tomographic Coronary Angiography for Long-Term Major Adverse Cardiac Events after Liver Transplantation
Kim, Doo-Hwan
Kim, Young-Kug
Ha, Tae-Yong
Hwang, Shin
Kim, Wooil
Koo, Hyun-Jung
Yang, Dong-Hyun
Kang, Joon-Won
Lee, Sung-Gyu
JOURNAL OF CLINICAL MEDICINE, 2021, 10 (14)
[26] Epicardial Adipose Tissue Is Associated with Plaque Burden and Composition and Provides Incremental Value for the Prediction of Cardiac Outcome. A Clinical Cardiac Computed Tomography Angiography Study
Gitsioudis, Gitsios
Schmahl, Christina
Missiou, Anna
Voss, Andreas
Schuessler, Alena
Abdel-Aty, Hassan
Buss, Sebastian J.
Mueller, Dirk
Vembar, Mani
Bryant, Mark
Kauczor, Hans-Ulrich
Giannitsis, Evangelos
Katus, Hugo A.
Korosoglou, Grigorios
PLOS ONE, 2016, 11 (05):
[27] Age- and Sex-Specific Burden of Cardiovascular Disease Attributable to 5 Major and Modifiable Risk Factors in 10 Asian Countries of the Western Pacific Region
Huxley, Rachel R.
Hirakawa, Yoichiro
Hussain, Mohammad Akhtar
Aekplakorn, Wichai
Wang, Xin
Peters, Sanne A. E.
Mamun, Abdullah
Woodward, Mark
CIRCULATION JOURNAL, 2015, 79 (08) : 1662 - U262
[28] Synergistic value of fractional flow reserve and low-density non-calcified plaque based on coronary computed tomography angiography for the identification of lesion-specific ischemia
Tang, Lin-Meng
Liu, Feng
Dong, Ting-Yu
Yang, Fei
Cui, Shu-Jun
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2022, 24 (05)
[29] Incremental prognostic value of coronary computed tomographic angiography over coronary artery calcium score for risk prediction of major adverse cardiac events in asymptomatic diabetic individuals
Min, James K.
Labounty, Troy M.
Gomez, Millie J.
Achenbach, Stephan
Al-Mallah, Mouaz
Budoff, Matthew J.
Cademartiri, Filippo
Callister, Tracy Q.
Chang, Hyuk-Jae
Cheng, Victor
Chinnaiyan, Kavitha M.
Chowk, Benjamin
Cury, Ricardo
Delago, Augustin
Dunning, Allison
Feuchtner, Gudrun
Hadamitzky, Martin
Hausleiter, Jorg
Kaufmann, Philipp
Kim, Yong-Jin
Leipsic, Jonathon
Lin, Fay Y.
Maffei, Erica
Raff, Gilbert
Shaw, Leslee J.
Villines, Todd C.
Berman, Daniel S.
ATHEROSCLEROSIS, 2014, 232 (02) : 298 - 304
[30] Quantitative global plaque characteristics from coronary computed tomography angiography for the prediction of future cardiac mortality during long-term follow-up
Hell, Michaela M.
Motwani, Manish
Otaki, Yuka
Cadet, Sebastien
Gransar, Heidi
Miranda-Peats, Romalisa
Valk, Jacob
Slomka, Piotr J.
Cheng, Victor Y.
Rozanski, Alan
Tamarappoo, Balaji K.
Hayes, Sean
Achenbach, Stephan
Berman, Daniel S.
Dey, Damini
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, 2017, 18 (12) : 1331 - 1339

← 1 2 3 4 →