Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus

被引：173

作者：

Yang, Xing-Lou ^{[1
,2
]}

Hu, Ben ^{[1
,2
]}

Wang, Bo ^{[1
,2
]}

Wang, Mei-Niang ^{[1
,2
]}

Zhang, Qian ^{[1
,2
]}

Zhang, Wei ^{[1
,2
]}

Wu, Li-Jun ^{[1
,2
]}

Ge, Xing-Yi ^{[1
,2
]}

Zhang, Yun-Zhi ^{[3
]}

Daszak, Peter ^{[4
]}

Wang, Lin-Fa ^{[5
]}

Shi, Zheng-Li ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Wuhan Inst Virol, Key Lab Special Pathogens, Wuhan, Peoples R China

[2] Chinese Acad Sci, Wuhan Inst Virol, Ctr Emerging Infect Dis, Wuhan, Peoples R China

[3] Yunnan Inst Endem Dis Control & Prevent, Dali, Peoples R China

[4] EcoHlth Alliance, New York, NY USA

[5] Duke NUS Grad Med Sch, Program Emerging Infect Dis, Singapore, Singapore

来源：

JOURNAL OF VIROLOGY | 2016年 / 90卷 / 06期

基金：

美国国家卫生研究院; 中国国家自然科学基金; 新加坡国家研究基金会;

关键词：

SARS-LIKE CORONAVIRUSES; GENOMIC CHARACTERIZATION; HORSESHOE BATS; PROTEIN; ORIGIN;

D O I：

10.1128/JVI.02582-15

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We report the isolation and characterization of a novel bat coronavirus which is much closer to the severe acute respiratory syndrome coronavirus (SARS-CoV) in genomic sequence than others previously reported, particularly in its S gene. Cell entry and susceptibility studies indicated that this virus can use ACE2 as a receptor and infect animal and human cell lines. Our results provide further evidence of the bat origin of the SARS-CoV and highlight the likelihood of future bat coronavirus emergence in humans.

引用

页码：3253 / 3256

页数：4

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