A New Brominated Norsesquiterpene Glycoside From the Rhizomes of Acorus tatarinowii Schott

被引：2

作者：

Hao, Zhi-You ^{[1
,2
]}

Ni, Gang ^{[2
]}

Liang, Dong ^{[2
,3
]}

Liu, Yan-Fei ^{[2
]}

Zhang, Chun-Lei ^{[2
,4
]}

Wang, Yan ^{[2
]}

Zhang, Qing-Jian ^{[2
]}

Chen, Ruo-Yun ^{[2
]}

Yu, De-Quan ^{[2
]}

机构：

[1] Henan Univ Chinese Med, Sch Pharm, Zhengzhou 450046, Peoples R China

[2] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing, Peoples R China

[3] Guangxi Ial Univ, Sch Chem & Pharmaceut Sci, Guilin, Peoples R China

[4] China Pharmaceut Univ, Sch Tradit Chinese Pharm, Nanjing, Peoples R China

来源：

NATURAL PRODUCT COMMUNICATIONS | 2021年 / 16卷 / 02期

关键词：

Acorns tatarinowii Schott; acoruside; brominated norsesquiterpene glycoside; structural elucidation; bioactivities; CHEMICAL-CONSTITUENTS; SESQUITERPENOIDS;

D O I：

10.1177/1934578X21992266

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new brominated norsesquiterpene glycoside, acoruside (1), has been isolated from the rhizomes of Acorus tatarinowii Schott, together with 8 known compounds (2-9). Their structures were elucidated mainly based on 1-dimensional (1D) and 2D nuclear magnetic resonance spectra. The absolute configuration of compound 1 was determined by comparing its experimental and calculated electronic circular dichroism spectra. The in vitro tests indicated that at 10 mu M, compounds 2, 3, and 4 aggravated serum deprivation injuries of PC12 cells, compound 2 aggravated rotenone-induced injuries of PC12 cells, and compounds 3 and 4 aggravated the oxygen-glucose deprivation-induced injuries of PC12 cells.

引用

页数：6

共 36 条

[1] Acorus tatarinowii Schott extract protects PC12 cells from amyloid-β induced neurotoxicity
An, Hong-Mei
Li, Guo-Wen
Lin, Chen
Gu, Chao
Jin, Miao
Sun, Wen-Xian
Qiu, Ming-Feng
Hu, Bing
[J]. PHARMAZIE, 2014, 69 (05): : 391 - 395
[2] Plant uptake of non-ionic organic chemicals
Collins, C
Fryer, M
Grosso, A
[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2006, 40 (01) : 45 - 52
[3] Cytotoxic and aromatic constituents from Salvia miltiorrhiza
Don, MJ
Shen, CC
Syu, WJ
Ding, YH
Sun, CM
[J]. PHYTOCHEMISTRY, 2006, 67 (05) : 497 - 503
[4] Fang JG., 2004, CHIN TRADIT HERB DRU, V35, P845
[5] New sesquiterpenoids from the rhizomes of Acorus tatarinowii
Feng, Xiao-Lin
Yu, Yang
Gao, Hao
Mu, Zhen-Qiang
Cheng, Xiao-Rui
Zhou, Wen-Xia
Yao, Xin-Sheng
[J]. RSC ADVANCES, 2014, 4 (79): : 42071 - 42077
[6] A recent survey of naturally occurring organohalogen compounds
Gribble, Gordon W.
[J]. ENVIRONMENTAL CHEMISTRY, 2015, 12 (04) : 396 - 405
[7] RECENTLY DISCOVERED NATURALLY OCCURRING HETEROCYCLIC ORGANOHALOGEN COMPOUNDS
Gribble, Gordon W.
[J]. HETEROCYCLES, 2012, 84 (01) : 157 - 207
[8] The diversity of naturally occurring organobromine compounds
Gribble, GW
[J]. CHEMICAL SOCIETY REVIEWS, 1999, 28 (05) : 335 - 346
[9] Naturally occurring organohalogen compounds
Gribble, GW
[J]. ACCOUNTS OF CHEMICAL RESEARCH, 1998, 31 (03) : 141 - 152
[10] HARA S, 1987, CHEM PHARM BULL, V35, P501

← 1 2 3 4 →