Reactive oxygen species-dependent signaling regulates cancer

被引：211

作者：

Weinberg, Frank ^{[2
]}

Chandel, Navdeep S. ^{[1
,2
]}

机构：

[1] Northwestern Univ, Sch Med, Dept Cell & Mol Biol, Chicago, IL 60611 USA

[2] Northwestern Univ, Sch Med, Dept Med, Div Pulm & Crit Care Med, Chicago, IL 60611 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2009年 / 66卷 / 23期

关键词：

Mitochondria; HIF; ROS; Metastasis; Tumorigenesis; NADPH oxidase; MANGANESE SUPEROXIDE-DISMUTASE; MITOCHONDRIAL-COMPLEX-III; CELL-CYCLE ARREST; HYPOXIA-INDUCIBLE FACTOR-1-ALPHA; PROTEIN-TYROSINE-PHOSPHATASE; HUMAN ENDOTHELIAL-CELLS; HUMAN TUMOR-CELLS; HYDROGEN-PEROXIDE; REDOX-REGULATION; HIF-ALPHA;

D O I：

10.1007/s00018-009-0099-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Historically, it has been assumed that oxidative stress contributes to tumor initiation and progression solely by inducing genomic instability. Recent studies indicate that reactive oxygen species are upregulated in tumors and can lead to aberrant induction of signaling networks that cause tumorigenesis and metastasis. Here we review the role of redox-dependent signaling pathways and transcription factors that regulate tumorigenesis.

引用

页码：3663 / 3673

页数：11

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