CD34: To select or not to select? That is the question

被引：39

作者：

Dao, MA ^{[1
]}

Nolta, JA ^{[1
]}

机构：

[1] Univ So Calif, Childrens Hosp Los Angeles, Sch Med,Dept Pediat, Div Res Immunol Bone Marrow Transplantat, Los Angeles, CA 90027 USA

来源：

LEUKEMIA | 2000年 / 14卷 / 05期

关键词：

CD34; hematopoietic stem cells; transplantation;

D O I：

10.1038/sj.leu.2401781

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent evidence suggests that expression of CD34 on the cell membrane does not always correlate with stem cell activity. In the mouse, there is a highly quiescent population of stem cells that lacks CD34 expression, but has full reconstituting capacity. The current review addresses the discovery of a similar population of dormant CD34-negative human hematopoietic stem cells. This information casts some uncertainty on the benefits of CD34(+) cell isolation for stem cell transplantation, until more is known about the novel CD34-negative stem cell population. Methods designed to achieve removal of specific mature blood cell lineages might prove to be most advantageous in the future.

引用

收藏

页码：773 / 776

页数：4

相关论文

共 38 条

[1] A newly discovered class of human hematopoietic cells with SCID-repopulating activity [J].

Bhatia, M ;

Bonnet, D ;

Murdoch, B ;

Gan, OI ;

Dick, JE .

NATURE MEDICINE, 1998, 4 (09) :1038-1045

[2] Treatment of autoimmune disease by intense immunosuppressive conditioning and autologous hematopoietic stem cell transplantation [J].

Burt, RK ;

Traynor, AE ;

Pope, R ;

Schroeder, J ;

Cohen, B ;

Karlin, KH ;

Lobeck, L ;

Goolsby, C ;

Rowlings, P ;

Davis, FA ;

Stefoski, D ;

Terry, C ;

Keever-Taylor, C ;

Rosen, S ;

Vesole, D ;

Fishman, M ;

Brush, M ;

Mujias, S ;

Villa, M ;

Burns, WH .

BLOOD, 1998, 92 (10) :3505-3514

[3] Stable transduction of quiescent CD34+CD38- human hematopoietic cells by HIV-1-based lentiviral vectors [J].

Case, SS ;

Price, MA ;

Jordan, CT ;

Yu, XJ ;

Wang, LJ ;

Bauer, G ;

Haas, DL ;

Xu, DK ;

Stripecke, R ;

Naldini, L ;

Kohn, DB ;

Crooks, GM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (06) :2988-2993

[4] Adhesion to fibronectin maintains regenerative capacity during ex vivo culture and transduction of human hematopoietic stem and progenitor cells [J].

Dao, MA ;

Hashino, K ;

Kato, I ;

Nolta, JA .

BLOOD, 1998, 92 (12) :4612-4621

[5] Engraftment and retroviral marking of CD34+ and CD34+CD38- human hematopoietic progenitors assessed in immune-deficient mice [J].

Dao, MA ;

Shah, AJ ;

Crooks, GM ;

Nolta, JA .

BLOOD, 1998, 91 (04) :1243-1255

[6] Molecular control of cell cycle progression in primary human hematopoietic stem cells: methods to increase levels of retroviral-mediated transduction [J].

Dao, MA ;

Nolta, JA .

LEUKEMIA, 1999, 13 (10) :1473-1480

[7]

Dao MA, 1997, CYTOKINES CELL MOL T, V3, P81

[8] Immunodeficient mice as models of human hematopoietic stem cell engraftment [J].

Dao, MA ;

Nolta, JA .

CURRENT OPINION IN IMMUNOLOGY, 1999, 11 (05) :532-537

[9] Reduction in levels of the cyclin-dependent kinase inhibitor p27kip-1 coupled with transforming growth factor β neutralization induces cell-cycle entry and increases retroviral transduction of primitive human hematopoietic cells [J].

Dao, MA ;

Taylor, N ;

Nolta, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (22) :13006-13011

[10] FLT3 ligand preserves the ability of human CD34(+) progenitors to sustain long-term hematopoiesis in immune-deficient mice after ex vivo retroviral-mediated transduction [J].

Dao, MA ;

Hannum, CH ;

Kohn, DB ;

Nolta, JA .

BLOOD, 1997, 89 (02) :446-456

← 1 2 3 4 →