Placenta growth factor and sFlt-1 as biomarkers in ischemic heart disease and heart failure: a review

被引：26
作者：
Draker, Nicole [1 ]
Torry, Donald S. [2 ]
Torry, Ronald J. [1 ]
机构：
[1] Drake Univ, Dept Pharmaceut & Adm Sci, Ellis Pharmacogen Lab, Coll Pharm & Hlth Sci, Des Moines, IA 50311 USA
[2] Southern Illinois Univ, Sch Med, Dept OB GYN, Dept Med Microbiol Immunol & Cell Biol, Springfield, IL 62702 USA
来源：
BIOMARKERS IN MEDICINE | 2019年 / 13卷 / 09期
关键词：
biomarkers; coronary artery disease; diagnosis; heart failure; placenta growth factor; PlGF; prognosis; sFlt-1; soluble fms-like tyrosine kinase receptor-1; TYROSINE KINASE 1; CORONARY MICROVASCULAR DYSFUNCTION; PRESERVED EJECTION FRACTION; CARDIAC BIOMARKERS; ENDOTHELIAL-CELLS; FACTOR EXPRESSION; FACTOR RECEPTOR-1; ADVERSE OUTCOMES; SERUM-LEVELS; CARDIOVASCULAR EVENTS;
D O I：
10.2217/bmm-2018-0492
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Coronary heart disease (CHD) and heart failure (HF) produce significant morbidity/mortality but identifying new biomarkers could help in the management of each. In this article, we summarize the molecular regulation and biomarker potential of PIGF and sFlt-1 in CHD and HF. PlGF is elevated during ischemia and some studies have shown PlGF, sFlt-1 or PlGF: sFlt-1 ratio, when used in combination with standard biomarkers, strengthens predictions of outcomes. sFlt-1 and PlGF are elevated in HF with sFlt-1 as a stronger predictor of outcomes. Although promising, we discuss additional study criteria needed to confirm the clinical usefulness of PlGF or sFlt-1 in the detection and management of CHD or HF.
引用
收藏
页码：785 / 799
页数：15
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