New and Repurposed Drugs for Pediatric Multidrug-Resistant Tuberculosis Practice-based Recommendations

被引：54

作者：

Harausz, Elizabeth P. ^{[1
]}

Garcia-Prats, Anthony J. ^{[2
]}

Seddon, James A. ^{[3
]}

Schaaf, H. Simon ^{[2
]}

Hesseling, Anneke C. ^{[2
]}

Achar, Jay ^{[4
]}

Bernheimer, Jonathan ^{[5
]}

Cruz, Andrea T. ^{[6
]}

D'Ambrosio, Lia ^{[7
,8
]}

Detjen, Anne ^{[9
]}

Graham, Stephen M. ^{[10
,11
]}

Hughes, Jennifer ^{[5
]}

Jonckheere, Sylvie ^{[12
]}

Marais, Ben J. ^{[13
]}

Migliori, Giovanni Battista ^{[7
]}

McKenna, Lindsay ^{[14
]}

Skrahina, Alena ^{[15
]}

Tadolini, Marina ^{[16
]}

Wilson, Peyton ^{[17
]}

Furin, Jennifer ^{[18
]}

机构：

[1] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA

[2] Stellenbosch Univ, Desmond Tutu TB Ctr, Dept Paediat & Child Hlth, Fac Med & Hlth Sci, Cape Town, South Africa

[3] Imperial Coll London, Ctr Int Child Hlth, London, England

[4] Medecins Sans Frontieres, Manson Unit, London, England

[5] Medecins Sans Frontieres, Khayelitsha, South Africa

[6] Baylor Coll Med, Houston, TX 77030 USA

[7] Salvatore Maugeri Fdn, Tradate, Italy

[8] Publ Hlth Consulting Grp, Lugano, Switzerland

[9] United Nations Childrens Fund, New York, NY USA

[10] Univ Melbourne, Ctr Int Child Hlth, Dept Paediat, Melbourne, Vic, Australia

[11] Royal Childrens Hosp, Murdoch Childrens Res Inst, Melbourne, Vic, Australia

[12] Medecins Sans Frontieres, Bombay, Maharashtra, India

[13] Univ Sydney, Childrens Hosp Westmead, Sydney, NSW, Australia

[14] Treatment Act Grp, HIV TB Project, New York, NY USA

[15] Republican Res & Pract Ctr Pulmonol & TB, Minsk, BELARUS

[16] Univ Bologna, Alma Mater Studiorum, Unit Infect Dis, Dept Med & Surg Sci, Bologna, Italy

[17] Boston Childrens Hosp, Dept Med, Boston, MA USA

[18] Harvard Med Sch, Dept Global Hlth & Social Med, Boston, MA USA

来源：

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | 2017年 / 195卷 / 10期

基金：

英国医学研究理事会;

关键词：

multidrug-resistant tuberculosis; Mycobacterium tuberculosis; child; adolescent; pediatric; COMPASSIONATE USE; CHILDREN; BEDAQUILINE; DELAMANID; REGIMEN; TOLERABILITY; PROLONGATION; EXPERIENCE; MANAGEMENT; NEVIRAPINE;

D O I：

10.1164/rccm.201606-1227CI

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

It is estimated that 33,000 children develop multidrug-resistant tuberculosis (MDR-TB) each year. In spite of these numbers, children and adolescents have limited access to the new and repurposed MDR-TB drugs. There is also little clinical guidance for the use of these drugs and for the shorter MDR-TB regimen in the pediatric population. This is despite the fact that these drugs and regimens are associated with improved interim outcomes and acceptable safety profiles in adults. This review fills a gap in the pediatric MDR-TB literature by providing practice-based recommendations for the use of the new (delamanid and bedaquiline) and repurposed (linezolid and clofazimine) MDR-TB drugs and the new shorter MDR-TB regimen in children and adolescents.

引用

页码：1300 / 1310

页数：11

共 50 条

[31] Managing multidrug-resistant tuberculosis in children: review of recent developments [J].

Schaaf, H. Simon ;

Garcia-Prats, Anthony J. ;

Hesseling, Anneke C. ;

Seddon, James A. .

CURRENT OPINION IN INFECTIOUS DISEASES, 2014, 27 (03) :211-219

[32] Treatment of Multidrug-resistant Tuberculosis Infection in Children [J].

Cruz, Andrea T. ;

Garcia-Prats, Anthony J. ;

Furin, Jennifer ;

Seddon, James A. .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2018, 37 (08) :831-834

[33] Treatment of Multidrug-Resistant Tuberculosis Infection in Children [J].

Cruz, Andrea T. ;

Garcia-Prats, Anthony J. ;

Furin, Jennifer ;

Seddon, James A. .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2018, 37 (10) :1061-1064

[34] Treatment Outcomes Among Pediatric Patients With Highly Drug-Resistant Tuberculosis: The Role of New and Repurposed Second-Line Tuberculosis Drugs [J].

Madzgharashvili, Tea ;

Salindri, Argita D. ;

Magee, Matthew J. ;

Tukvadze, Nestani ;

Avaliani, Zaza ;

Blumberg, Henry M. ;

Kempker, Russell R. ;

Lomtadze, Nino .

JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY, 2021, 10 (04) :457-467

[35] Treatment outcomes of multidrug-resistant TB with selective use of new drugs [J].

Kwon, Y-S. ;

Shin, J. E. ;

Kang, H. ;

Jeon, D. ;

Yim, J-J. ;

Shim, T. S. .

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 2023, 27 (01) :55-+

[36] Delamanid and bedaquiline to treat multidrug-resistant and extensively drug-resistant tuberculosis in children: a systematic review [J].

D'Ambrosio, Lia ;

Centis, Rosella ;

Tiberi, Simon ;

Tadolini, Marina ;

Dalcolmo, Margareth ;

Rendon, Adrian ;

Esposito, Susanna ;

Migliori, Giovanni Battista .

JOURNAL OF THORACIC DISEASE, 2017, 9 (07) :2093-2101

[37] Multidrug-resistant Tuberculosis [J].

Lynch, John B. .

MEDICAL CLINICS OF NORTH AMERICA, 2013, 97 (04) :553-+

[38] New treatment options for multidrug-resistant tuberculosis [J].

Field, Stephen K. ;

Fisher, Dina ;

Jarand, Julie M. ;

Cowie, Robert L. .

THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE, 2012, 6 (05) :255-268

[39] Tuberculosis among young contacts of patients with multidrug-resistant pulmonary tuberculosis in a reference hospital [J].

Rubin, Evelyn F. ;

Lucena, Sheila C. ;

Bhering, Marcela ;

Goncalves, Lorrayne ;

Falcao, Fabiana ;

Dalcolmo, Margareth ;

Migliori, Giovanni B. ;

Saderi, Laura ;

Sotgiu, Giovanni ;

Kritski, Afranio ;

Carvalho, Anna C. C. .

JORNAL DE PEDIATRIA, 2025, 101 (03) :458-465

[40] Clinical management of adults and children with multidrug-resistant and extensively drug-resistant tuberculosis [J].

Dheda, K. ;

Chang, K. C. ;

Guglielmetti, L. ;

Furin, J. ;

Schaaf, H. S. ;

Chesov, D. ;

Esmail, A. ;

Lange, C. .

CLINICAL MICROBIOLOGY AND INFECTION, 2017, 23 (03) :131-140

← 1 2 3 4 5 →