New and Repurposed Drugs for Pediatric Multidrug-Resistant Tuberculosis Practice-based Recommendations

被引：52

作者：

Harausz, Elizabeth P. ^{[1
]}

Garcia-Prats, Anthony J. ^{[2
]}

Seddon, James A. ^{[3
]}

Schaaf, H. Simon ^{[2
]}

Hesseling, Anneke C. ^{[2
]}

Achar, Jay ^{[4
]}

Bernheimer, Jonathan ^{[5
]}

Cruz, Andrea T. ^{[6
]}

D'Ambrosio, Lia ^{[7
,8
]}

Detjen, Anne ^{[9
]}

Graham, Stephen M. ^{[10
,11
]}

Hughes, Jennifer ^{[5
]}

Jonckheere, Sylvie ^{[12
]}

Marais, Ben J. ^{[13
]}

Migliori, Giovanni Battista ^{[7
]}

McKenna, Lindsay ^{[14
]}

Skrahina, Alena ^{[15
]}

Tadolini, Marina ^{[16
]}

Wilson, Peyton ^{[17
]}

Furin, Jennifer ^{[18
]}

机构：

[1] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA

[2] Stellenbosch Univ, Desmond Tutu TB Ctr, Dept Paediat & Child Hlth, Fac Med & Hlth Sci, Cape Town, South Africa

[3] Imperial Coll London, Ctr Int Child Hlth, London, England

[4] Medecins Sans Frontieres, Manson Unit, London, England

[5] Medecins Sans Frontieres, Khayelitsha, South Africa

[6] Baylor Coll Med, Houston, TX 77030 USA

[7] Salvatore Maugeri Fdn, Tradate, Italy

[8] Publ Hlth Consulting Grp, Lugano, Switzerland

[9] United Nations Childrens Fund, New York, NY USA

[10] Univ Melbourne, Ctr Int Child Hlth, Dept Paediat, Melbourne, Vic, Australia

[11] Royal Childrens Hosp, Murdoch Childrens Res Inst, Melbourne, Vic, Australia

[12] Medecins Sans Frontieres, Bombay, Maharashtra, India

[13] Univ Sydney, Childrens Hosp Westmead, Sydney, NSW, Australia

[14] Treatment Act Grp, HIV TB Project, New York, NY USA

[15] Republican Res & Pract Ctr Pulmonol & TB, Minsk, BELARUS

[16] Univ Bologna, Alma Mater Studiorum, Unit Infect Dis, Dept Med & Surg Sci, Bologna, Italy

[17] Boston Childrens Hosp, Dept Med, Boston, MA USA

[18] Harvard Med Sch, Dept Global Hlth & Social Med, Boston, MA USA

来源：

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | 2017年 / 195卷 / 10期

基金：

英国医学研究理事会;

关键词：

multidrug-resistant tuberculosis; Mycobacterium tuberculosis; child; adolescent; pediatric; COMPASSIONATE USE; CHILDREN; BEDAQUILINE; DELAMANID; REGIMEN; TOLERABILITY; PROLONGATION; EXPERIENCE; MANAGEMENT; NEVIRAPINE;

D O I：

10.1164/rccm.201606-1227CI

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

It is estimated that 33,000 children develop multidrug-resistant tuberculosis (MDR-TB) each year. In spite of these numbers, children and adolescents have limited access to the new and repurposed MDR-TB drugs. There is also little clinical guidance for the use of these drugs and for the shorter MDR-TB regimen in the pediatric population. This is despite the fact that these drugs and regimens are associated with improved interim outcomes and acceptable safety profiles in adults. This review fills a gap in the pediatric MDR-TB literature by providing practice-based recommendations for the use of the new (delamanid and bedaquiline) and repurposed (linezolid and clofazimine) MDR-TB drugs and the new shorter MDR-TB regimen in children and adolescents.

引用

页码：1300 / 1310

页数：11

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