Synthesis, phytotoxic, cytotoxic, acetylcholinesterase and butrylcholinesterase activities of N,N′-diaryl unsymmetrically substituted thioureas

被引：17

作者：

Begum, Saeedan ^{[1
]}

Choudhary, M. Iqbal ^{[1
]}

Khan, Khalid M. ^{[1
]}

机构：

[1] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 5270, Pakistan

来源：

NATURAL PRODUCT RESEARCH | 2009年 / 23卷 / 18期

关键词：

N; N '-diaryl unsymmetrically substituted thiourea derivatives; phytotoxicity; cytotoxicity; acetylcholinesterase activity; butrylcholinesterase activity; CYTOKININ ACTIVITY; DERIVATIVES; POTENT; INHIBITORS; DESIGN;

D O I：

10.1080/14786410802223778

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Fourteen N,N'-diaryl unsymmetrically substituted thioureas were synthesised and their cytotoxic ( in vitro), phytotoxic ( in vitro), acetylcholinesterase and butrylcholinesterase activities were determined. Thiourea 16 exhibited high, and 1 and 3 showed significant phytotoxic activity. Thioureas 1, 3, 4, 6 and 10 showed significant activity and 2, 6 and 7 indicated moderate cytotoxic activities. Compound 12 exhibited butrylcholinesterase activity higher than a standard reference.

引用

页码：1719 / 1730

页数：12

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