No Rebound of Morbidity Following Intermittent Preventive Sulfadoxine-Pyrimethamine Treatment of Malaria in Infants in Gabon

被引：14

作者：

Grobusch, Martin P. ^{[1
,2
,3
,4
]}

Gabor, Julian J. ^{[1
,2
]}

Aponte, John J. ^{[5
,6
]}

Schwarz, Norbert G. ^{[1
,2
]}

Poetschke, Marc ^{[1
,2
]}

Doernemann, Jenny ^{[1
,2
]}

Schuster, Katharina ^{[1
,2
]}

Koester, Kai B. ^{[1
,2
]}

Profanter, Katharina ^{[1
,2
]}

Borchert, Lea B. ^{[1
,2
]}

Kurth, Florian ^{[1
,2
]}

Pongratz, Peter ^{[1
,2
]}

Issifou, Saadou ^{[1
]}

Lell, Bertrand ^{[1
,2
]}

Kremsner, Peter G. ^{[1
,2
]}

机构：

[1] Albert Schweitzer Hosp, Med Res Unit, Lambarene, Gabon

[2] Univ Tubingen, Inst Trop Med, Tubingen, Germany

[3] Univ Witwatersrand, Natl Hlth Lab Serv, Infect Dis Unit, Div Clin Microbiol & Infect Dis, ZA-2193 Johannesburg, South Africa

[4] Univ Witwatersrand, Fac Hlth Sci, Sch Pathol, ZA-2193 Johannesburg, South Africa

[5] Univ Barcelona, Barcelona Ctr Int Hlth Res CRESIB, Hosp Clin, IDIBAPS, Barcelona, Spain

[6] Manhica CISM, Manhica Hlth Res Ctr, Manhica, Mozambique

来源：

JOURNAL OF INFECTIOUS DISEASES | 2009年 / 200卷 / 11期

关键词：

PLACEBO-CONTROLLED TRIAL; ROUTINE VACCINATIONS; TANZANIAN INFANTS; DOUBLE-BLIND; ANEMIA; TIME;

D O I：

10.1086/647990

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the context of a trial studying intermittent preventive sulfadoxine-pyrimethamine treatment of malaria in infants in Lambarene, Gabon, children aged 18-30 months were followed up after having received their last dose at an age of 15 months. In the intention-to-treat population, the protective efficacy against all malaria episodes was -18.0 (95% confidence interval, -97.4 to 29.5; P = .529). The protective efficacy against first or only anemia episode was -45.3 (95% confidence interval, -234.5 to 36.3; P = .375). The protective efficacies were negative and were not statistically significant. These results do not appear to support the concept of a rebound effect after intermittent preventive sulfadoxine-pyrimethamine treatment of malaria in infants.

引用

页码：1658 / 1661

页数：4

共 13 条

[1]

APONTE JJ, 2009, LANCET

[2] Age interactions in the development of naturally acquired immunity to Plasmodium falciparum and its clinical presentation [J].

Aponte, John J. ;

Menendez, Clara ;

Schellenberg, David ;

Kahigwa, Elizeus ;

Mshinda, Hassan ;

Vountasou, Penelope ;

Tanner, Marcel ;

Alonso, Pedro L. .

PLOS MEDICINE, 2007, 4 (07) :1259-1267

[3] Cluster randomised trial of intermittent preventive treatment for malaria in infants in area of high, seasonal transmission in Ghana [J].

Chandramohan, D ;

Owusu-Agyei, S ;

Carneiro, I ;

Awine, T ;

Amponsa-Achiano, K ;

Mensah, N ;

Jaffar, S ;

Baiden, R ;

Hodgson, A ;

Binka, F ;

Greenwood, B .

BMJ-BRITISH MEDICAL JOURNAL, 2005, 331 (7519) :727-733

[4] Mortality and morbidity from malaria after stopping malaria chemoprophylaxis [J].

Greenwood, BM ;

David, PH ;

OtooForbes, LN ;

Allen, SJ ;

Alonso, PL ;

Schellenberg, JRA ;

Byass, P ;

Hurwitz, M ;

Menon, A ;

Snow, RW .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1995, 89 (06) :629-633

[5] A COMPARATIVE-STUDY OF LAPUDRINE (CHLORPROGUANIL) AND MALOPRIM (PYRIMETHAMINE AND DAPSONE) AS CHEMOPROPHYLACTICS AGAINST MALARIA IN GAMBIAN CHILDREN [J].

GREENWOOD, BM ;

GREENWOOD, AM ;

SMITH, AW ;

MENON, A ;

BRADLEY, AK ;

SNOW, RW ;

SISAY, F ;

BENNETT, S ;

WATKINS, WM ;

NJIE, ABH .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1989, 83 (02) :182-188

[6] Intermittent preventive therapy for malaria: progress and future directions [J].

Grobusch, Martin P. ;

Egan, Andrea ;

Gosling, Roly D. ;

Newman, Robert D. .

CURRENT OPINION IN INFECTIOUS DISEASES, 2007, 20 (06) :613-620

[7] Intermittent preventive treatment against malaria in infants in Gabon -: A randomized, double-blind, placebo-controlled trial [J].

Grobusch, Martin P. ;

Lell, Bertrand ;

Schwarz, Norbert G. ;

Gabor, Julian ;

Dornemann, Jenny ;

Poetschke, Marc ;

Oyakhirome, Sunny ;

Kiessling, Georg C. ;

Necek, Magdalena ;

Laengin, Matthias U. ;

Klouwenberg, Peter Klein ;

Kloepfer, Anna ;

Naumann, Benjamin ;

Altun, Handan ;

Agnandji, Selidji T. ;

Goesch, Julia ;

Decker, Marieluise ;

Salazar, Carmen L. Ospina ;

Supan, Christian ;

Kombila, Davy U. ;

Borchert, Lea ;

Koester, Kai B. ;

Pongratz, Peter ;

Adegnika, Akim A. ;

von Glasenapp, Isabelle ;

Issifou, Saadou ;

Kremsner, Peter G. .

JOURNAL OF INFECTIOUS DISEASES, 2007, 196 (11) :1595-1602

[8] A randomized controlled trial of extended intermittent preventive antimalarial treatment in infants [J].

Kobbe, Robin ;

Kreuzberg, Christina ;

Adjei, Samuel ;

Thompson, Benedicta ;

Langefeld, Iris ;

Thompson, Peter Apia ;

Abruquah, Harry Hoffman ;

Kreuels, Benno ;

Ayim, Matilda ;

Busch, Wibke ;

Marks, Florian ;

Amoah, Kwado ;

Opoku, Ernest ;

Meyer, Christian G. ;

Adjei, Ohene ;

May, Juergen .

CLINICAL INFECTIOUS DISEASES, 2007, 45 (01) :S16-S25

[9] Intermittent preventive treatment for malaria control administered at the time of routine vaccinations in Mozambican infants:: A randomized, placebo-controlled trial [J].

Macete, Eusebio ;

Aide, Pedro ;

Aponte, John J. ;

Sanz, Sergi ;

Mandomando, Inacio ;

Espasa, Mateu ;

Sigauque, Betuel ;

Dobano, Carlota ;

Mabunda, Samuel ;

DgeDge, Martinho ;

Alonso, Pedro ;

Menendez, Clara .

JOURNAL OF INFECTIOUS DISEASES, 2006, 194 (03) :276-285

[10] Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants [J].

Menendez, C ;

Kahigwa, E ;

Hirt, R ;

Vounatsou, P ;

Aponte, JJ ;

Font, F ;

Acosta, CJ ;

Schellenberg, DM ;

Galindo, CM ;

Kimario, J ;

Urassa, H ;

Brabin, B ;

Smith, TA ;

Kitua, AY ;

Tanner, M ;

Alonso, PL .

LANCET, 1997, 350 (9081) :844-850

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