Synthesis of N-(1-aziridinyl)-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acids

被引：2

作者：

Batori, S ^{[1
]}

Timari, G ^{[1
]}

Messmer, A ^{[1
]}

Podanyi, B ^{[1
]}

VasvariDebreczy, L ^{[1
]}

Hermecz, I ^{[1
]}

机构：

[1] HUNGARIAN ACAD SCI,CENT RES INST CHEM,H-1525 BUDAPEST,HUNGARY

来源：

HETEROCYCLES | 1997年 / 45卷 / 06期

关键词：

D O I：

10.3987/COM-97-7770

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of N-(1-aziridinyl)quinoline-3-carboxylic acid derivatives (e.g. 11a-f, 20a-g, 21a-d) have been synthesized by insertion reaction of nitrenes (e.g. ethyl 7-chloro-6-fluoro-1-nitreno-1,4-dihydro-4-oxoquinoline-3-carboxylate (9)) into double bond of different olefins (e.g. styrene (10a), see Schemes 2 and 4). The nitrenes were formed in situ by oxidation of N-aminoquinolin-4(1H)-one derivatives (8, 18a,b) using Pb(OAc)(4) as oxidizing agent.

引用

页码：1097 / 1110

页数：14

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