AIE Luminogen-Functionalized Hollow Mesoporous Silica Nanospheres for Drug Delivery and Cell Imaging

被引：51

作者：

Fan, Zhiying ^{[1
]}

Li, Dongdong ^{[1
,3
]}

Yu, Xue ^{[2
]}

Zhang, Yuping ^{[1
]}

Cai, Yong ^{[2
]}

Jin, Jingji ^{[2
]}

Yu, Jihong ^{[1
]}

机构：

[1] Jilin Univ, Coll Chem, State Key Lab Inorgan Synth & Preparat Chem, 2699 Qianjin St, Changchun 130012, Peoples R China

[2] Jilin Univ, Sch Life Sci, 2699 Qianjin St, Changchun 130012, Peoples R China

[3] Jilin Univ, Dept Mat Sci, 2699 Qianjin St, Changchun 130012, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2016年 / 22卷 / 11期

基金：

中国国家自然科学基金;

关键词：

aggregation-induced emission; imaging agents; drug delivery; mesoporous materials; nanostructures; AGGREGATION-INDUCED EMISSION; NANOPARTICLES; NANOCAPSULES; RELEASE; MICROSPHERES;

D O I：

10.1002/chem.201504377

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hollow mesoporous silica nanospheres functionalized with aggregation-induced emission (AIE) luminogen tetraphenylethene were prepared by postgrafting method. The as-prepared inorganic-organic hybrid nanospheres show bright blue emission and good biocompatibility as shown by MTT assays. The large cavities of the materials enable high loading of the anticancer drug doxorubicin hydrochloride (DOX), and the mesoporous silica shells allow pH-dependent drug release. The materials can be effectively taken up by cells and function as luminescent bioprobes, demonstrating their potential application in imaging-guided therapy.

引用

页码：3681 / 3685

页数：5

共 34 条

[21] Functionalized Siloles: Versatile Synthesis, Aggregation-Induced Emission, and Sensory and Device Applications [J].

Li, Zhen ;

Dong, Yong Qiang ;

Lam, Jacky W. Y. ;

Sun, Jiaxin ;

Qin, Anjun ;

Haeussler, Matthias ;

Dong, Yu Ping ;

Sung, Herman H. Y. ;

Williams, Ian D. ;

Kwok, Hoi Sing ;

Tang, Ben Zhong .

ADVANCED FUNCTIONAL MATERIALS, 2009, 19 (06) :905-917

[22] Magnetic Nanocomposites with Mesoporous Structures: Synthesis and Applications [J].

Liu, Jian ;

Qiao, Shi Zhang ;

Hu, Qiu Hong ;

Lu, Gao Qing .

SMALL, 2011, 7 (04) :425-443

[23] Hollow Micro-/Nanostructures: Synthesis and Applications [J].

Lou, Xiong Wen ;

Archer, Lynden A. ;

Yang, Zichao .

ADVANCED MATERIALS, 2008, 20 (21) :3987-4019

[24] Preparation and characterization of (3-aminopropyl)triethoxysilane-modified mesoporous SBA-15 silica molecular sieves [J].

Luan, ZH ;

Fournier, JA ;

Wooten, JB ;

Miser, DE .

MICROPOROUS AND MESOPOROUS MATERIALS, 2005, 83 (1-3) :150-158

[25] Integrated Hollow Mesoporous Silica Nanoparticles for Target Drug/siRNA Co-Delivery [J].

Ma, Xing ;

Zhao, Yun ;

Ng, Kee Woei ;

Zhao, Yanli .

CHEMISTRY-A EUROPEAN JOURNAL, 2013, 19 (46) :15593-15603

[26] AIE luminogen functionalized mesoporous silica nanoparticles as efficient fluorescent sensor for explosives detection in water [J].

Miao, Chuanlong ;

Li, Dongdong ;

Zhang, Yuping ;

Yu, Jihong ;

Xu, Ruren .

MICROPOROUS AND MESOPOROUS MATERIALS, 2014, 196 :46-50

[27] On the development of colloidal nanoparticles towards multifunctional structures and their possible use for biological applications [J].

Pellegrino, T ;

Kudera, S ;

Liedl, T ;

Javier, AM ;

Manna, L ;

Parak, WJ .

SMALL, 2005, 1 (01) :48-63

[28] Nanorattles or Yolk-Shell Nanoparticles-What Are They, How Are They Made, and What Are They Good For? [J].

Priebe, Magdalena ;

Fromm, Katharina M. .

CHEMISTRY-A EUROPEAN JOURNAL, 2015, 21 (10) :3854-3874

[29] Insight into aggregation-induced emission characteristics of red-emissive quinoline-malononitrile by cell tracking and real-time trypsin detection [J].

Shao, Andong ;

Guo, Zhiqian ;

Zhu, Shaojia ;

Zhu, Shiqin ;

Shi, Ping ;

Tian, He ;

Zhu, Weihong .

CHEMICAL SCIENCE, 2014, 5 (04) :1383-1389

[30] Chemical sensors based on amplifying fluorescent conjugated polymers [J].

Thomas, Samuel W., III ;

Joly, Guy D. ;

Swager, Timothy M. .

CHEMICAL REVIEWS, 2007, 107 (04) :1339-1386

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