AIE Luminogen-Functionalized Hollow Mesoporous Silica Nanospheres for Drug Delivery and Cell Imaging

被引：51

作者：

Fan, Zhiying ^{[1
]}

Li, Dongdong ^{[1
,3
]}

Yu, Xue ^{[2
]}

Zhang, Yuping ^{[1
]}

Cai, Yong ^{[2
]}

Jin, Jingji ^{[2
]}

Yu, Jihong ^{[1
]}

机构：

[1] Jilin Univ, Coll Chem, State Key Lab Inorgan Synth & Preparat Chem, 2699 Qianjin St, Changchun 130012, Peoples R China

[2] Jilin Univ, Sch Life Sci, 2699 Qianjin St, Changchun 130012, Peoples R China

[3] Jilin Univ, Dept Mat Sci, 2699 Qianjin St, Changchun 130012, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2016年 / 22卷 / 11期

基金：

中国国家自然科学基金;

关键词：

aggregation-induced emission; imaging agents; drug delivery; mesoporous materials; nanostructures; AGGREGATION-INDUCED EMISSION; NANOPARTICLES; NANOCAPSULES; RELEASE; MICROSPHERES;

D O I：

10.1002/chem.201504377

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hollow mesoporous silica nanospheres functionalized with aggregation-induced emission (AIE) luminogen tetraphenylethene were prepared by postgrafting method. The as-prepared inorganic-organic hybrid nanospheres show bright blue emission and good biocompatibility as shown by MTT assays. The large cavities of the materials enable high loading of the anticancer drug doxorubicin hydrochloride (DOX), and the mesoporous silica shells allow pH-dependent drug release. The materials can be effectively taken up by cells and function as luminescent bioprobes, demonstrating their potential application in imaging-guided therapy.

引用

页码：3681 / 3685

页数：5

共 34 条

[1] Multifunctional Mesoporous Composite Nanocapsules for Highly Efficient MRI-Guided High-Intensity Focused Ultrasound Cancer Surgery [J].

Chen, Yu ;

Chen, Hangrong ;

Sun, Yang ;

Zheng, Yuanyi ;

Zeng, Deping ;

Li, Faqi ;

Zhang, Shengjian ;

Wang, Xia ;

Zhang, Kun ;

Ma, Ming ;

He, Qianjun ;

Zhang, Linlin ;

Shi, Jianlin .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (52) :12505-12509

[2] Reversible Pore-Structure Evolution in Hollow Silica Nanocapsules: Large Pores for siRNA Delivery and Nanoparticle Collecting [J].

Chen, Yu ;

Chu, Chen ;

Zhou, Yuchuan ;

Ru, Yanfei ;

Chen, Hangrong ;

Chen, Feng ;

He, Qianjun ;

Zhang, Yonglian ;

Zhang, Linlin ;

Shi, Jianlin .

SMALL, 2011, 7 (20) :2935-2944

[3] Up-Conversion Cell Imaging and pH-Induced Thermally Controlled Drug Release from NaYF4:Yb3+/Er3+@Hydrogel Core-Shell Hybrid Microspheres [J].

Dai, Yunlu ;

Ma, Ping'an ;

Cheng, Ziyong ;

Kang, Xiaojiao ;

Zhang, Xiao ;

Hou, Zhiyao ;

Li, Chunxia ;

Yang, Dongmei ;

Zhai, Xuefeng ;

Lin, Jun .

ACS NANO, 2012, 6 (04) :3327-3338

[4]

Derfus AM, 2004, NANO LETT, V4, P11, DOI 10.1021/nl0347334

[5] Bioprobes Based on AIE Fluorogens [J].

Ding, Dan ;

Li, Kai ;

Liu, Bin ;

Tang, Ben Zhong .

ACCOUNTS OF CHEMICAL RESEARCH, 2013, 46 (11) :2441-2453

[6] Spherical silica micro/nanomaterials with hierarchical structures: Synthesis and applications [J].

Du, Xin ;

He, Junhui .

NANOSCALE, 2011, 3 (10) :3984-4002

[7] Preparation of silica mesoporous nanoparticles functionalized with β-cyclodextrin and its application for methylene blue removal [J].

Ebadi, Azra ;

Rafati, Amir Abbas .

JOURNAL OF MOLECULAR LIQUIDS, 2015, 209 :239-245

[8] Selective Functionalization of Hollow Nanospheres with Acid and Base Groups for Cascade Reactions [J].

Gao, Jinsuo ;

Zhang, Xueying ;

Lu, Yong ;

Liu, Shaomin ;

Liu, Jian .

CHEMISTRY-A EUROPEAN JOURNAL, 2015, 21 (20) :7403-7407

[9] Aggregation-induced emission: phenomenon, mechanism and applications [J].

Hong, Yuning ;

Lam, Jacky W. Y. ;

Tang, Ben Zhong .

CHEMICAL COMMUNICATIONS, 2009, (29) :4332-4353

[10] Silica-based complex nanorattles as multifunctional carrier for anticancer drug [J].

Hu, Yong ;

Zheng, Xin Ting ;

Chen, Jun Song ;

Zhou, Mojiao ;

Li, Chang Ming ;

Lou, Xiong Wen .

JOURNAL OF MATERIALS CHEMISTRY, 2011, 21 (22) :8052-8056

← 1 2 3 4 →