Phenolics and neolignans isolated from the fruits of Juglans mandshurica Maxim. and their effects on lipolysis in adipocytes

被引:32
作者
Park, SeonJu [1 ]
Kim, Nanyoung [1 ]
Yoo, Guijae [1 ]
Kim, Sang-Nam [1 ]
Kwon, Hyun-Jung [1 ]
Jung, Kiwon [2 ]
Oh, Dong-Chan [3 ]
Lee, Yun-Hee [1 ]
Kim, Seung Hyun [1 ]
机构
[1] Yonsei Univ, Yonsei Inst Pharmaceut Sci, Coll Pharm, Incheon 21983, South Korea
[2] CHA Univ, Inst Pharmaceut Sci, Coll Pharm, Sungnam 13844, South Korea
[3] Seoul Natl Univ, Nat Prod Res Inst, Coll Pharm, Seoul 08826, South Korea
基金
新加坡国家研究基金会;
关键词
Juglans mandshurica Maxim; Juglandaceae; Neolignans; Anti-obesity; Lipolysis; O-2; consumption; ROOTS; CONSTITUENTS; LIGNANS; DIARYLHEPTANOIDS; DERIVATIVES; ANTIOXIDANT; HEARTWOOD; TISSUE; SEEDS;
D O I
10.1016/j.phytochem.2017.01.019
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Juglans mandshurica Maxim. (Juglandaceae) is a traditional folk medicine used for treatment of dermatosis and to relieve aches in Korea and China. In this study, eight compounds, along with six known compounds, were isolated from the fruit of J. mandshurica. Among the six known compounds, the absolute configuration of two compounds were determined. The structures of compounds were determined on the basis of extensive spectroscopic methods, including 10 and 2D NMR and CD spectroscopic data. All isolated compounds were tested for their lipolytic activities in differentiated adipocytes using C3H10T1/2 mouse embryonic fibroblasts. Among them, 2-(4-formyl-2-methoxyphenoxy)-propan-1,3-diol and 2-14-(3-hydroxypropy1)-2-methoxyphenoxyl-1,3-propanediol exhibited the most potent lipolytic activities. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码:87 / 93
页数:7
相关论文
共 31 条
  • [1] [Anonymous], 2015, Obesity and overweight
  • [2] The medical care costs of obesity: An instrumental variables approach
    Cawley, John
    Meyerhoefer, Chad
    [J]. JOURNAL OF HEALTH ECONOMICS, 2012, 31 (01) : 219 - 230
  • [3] Inhibitory effects of compounds isolated from fruit of Juglans mandshurica on pancreatic lipase
    Han, Likun
    Li, Wei
    Narimatsu, Sanae
    Liu, Lijuan
    Fu, Hongwei
    Okuda, Hiromichi
    Koike, Kazuo
    [J]. JOURNAL OF NATURAL MEDICINES, 2007, 61 (02) : 184 - 186
  • [4] HSIAO JJ, 1995, PHYTOCHEMISTRY, V39, P899, DOI 10.1016/0031-9422(95)00072-F
  • [5] The cytotoxicity of 8-O-4′ neolignans from the seeds of Crataegus pinnatifida
    Huang, Xiao-Xiao
    Zhou, Chen-Chen
    Li, Ling-Zhi
    Li, Fei-Fei
    Lou, Li-Li
    Li, Dian-Ming
    Ikejima, Takshi
    Peng, Ying
    Song, Shao-Jiang
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (20) : 5599 - 5604
  • [6] Anti-Obesity Drugs: A Review about Their Effects and Safety
    Kang, Jun Goo
    Park, Cheol-Young
    [J]. DIABETES & METABOLISM JOURNAL, 2012, 36 (01) : 13 - 25
  • [7] Cytotoxic compounds from the roots of Juglans mandshurica
    Kim, SH
    Lee, KS
    Son, JK
    Je, GH
    Lee, JS
    Lee, CH
    Cheong, CJ
    [J]. JOURNAL OF NATURAL PRODUCTS, 1998, 61 (05): : 643 - 645
  • [8] Aromatic constituents from the heartwood of Santalum album L.
    Kim, TH
    Ito, H
    Hayashi, K
    Hasegawa, T
    Machiguchi, T
    Yoshida, T
    [J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 2005, 53 (06) : 641 - 644
  • [9] KOUNO I, 1992, CHEM PHARM BULL, V40, P2461, DOI 10.1248/cpb.40.2461
  • [10] PHENOLIC-COMPOUNDS FROM ROOTS OF URTICA-DIOICA
    KRAUS, R
    SPITELLER, G
    [J]. PHYTOCHEMISTRY, 1990, 29 (05) : 1653 - 1659