The role of cystatins in cells of the immune system

被引：109
作者：
Kopitar-Jerala, Natasa [1 ]
机构：
[1] Jozef Stefan Inst, Dept Biochem & Mol Biol, Ljubljana 1000, Slovenia
来源：
FEBS LETTERS | 2006年 / 580卷 / 27期
关键词：
cystatin; cathepsin; macrophages; dendritic cells; natural killer cells;
D O I：
10.1016/j.febslet.2006.10.055
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The cystatins constitute a large group of evolutionary related proteins with diverse biological activities. Initially, they were characterized as inhibitors of lysosomal cysteine proteases-cathepsins. Cathepsins are involved in processing and presentation of antigens, as well as several pathological conditions such as inflammation and cancer. Recently, alternative functions of cystatins have been proposed: they also induce tumour necrosis factor and interleukin 10 synthesis and stimulate nitric oxide production. The aim of the present review was the analysis of data on cystatins from NCB1 GEO database and the literature, and obtained in microarray and serial analysis of gene expression (SAGE) experiments. The expression of cystatins A, B, C, and F in macrophages, dendritic cells and natural killer cells of the immune system, during differentiation and activation is discussed. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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收藏
页码：6295 / 6301
页数：7
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