2,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure-activity relationship, and docking study

被引：46

作者：

Basnet, Arjun ^{[1
]}

Thapa, Pritam ^{[1
]}

Karki, Radha ^{[1
]}

Choi, Hoyoung ^{[1
]}

Choi, Jae Hun ^{[1
]}

Yun, Minho ^{[1
]}

Jeong, Byeong-Seon ^{[1
]}

Jahng, Yurngdong ^{[1
]}

Na, Younghwa ^{[2
]}

Cho, Won-Jea ^{[3
]}

Kwon, Youngjoo ^{[4
]}

Lee, Chong-Soon ^{[5
]}

Lee, Eung-Seok ^{[1
]}

机构：

[1] Yeungnam Univ, Coll Pharm, Kyongsan 712749, South Korea

[2] Catholic Univ Daegu, Coll Pharm, Kyongsan 712702, South Korea

[3] Chonnam Natl Univ, Coll Pharm, Kwangju 500757, South Korea

[4] Ewha Womans Univ, Coll Pharm, Pharm & Div Life & Pharmaceut Sci, Seoul 120750, South Korea

[5] Yeungnam Univ, Dept Biochem, Kyongsan 712749, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 01期

关键词：

2,6-Dithienyl-4-furyl pyridine; Topoisomerase I and II inhibitor; Cytotoxicity; Antitumor agents; Docking study; SUBSTITUIERTER PYRIDINE; DNA-TOPOISOMERASES; EUROPIUM(III); COMPLEXES;

D O I：

10.1016/j.bmcl.2009.11.041

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

For the development of novel antitumor agents, 2,6-dithienyl-4-furyl pyridine derivatives were prepared and evaluated for their topoisomerase I and II inhibitory activity as well as cytotoxicity against several human cancer cell lines. Among the 21 prepared compounds, compound 24 exhibited strong topoisomerase I inhibitory activity. In addition, a docking study with topoisomerase I and compound 24 was performed. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：42 / 47

页数：6

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