Molecular mechanisms of nickel carcinogenesis

被引：74

作者：

Cangul, H

Broday, L

Salnikow, K

Sutherland, J

Peng, W

Zhang, Q

Poltaratsky, V

Yee, H

Zoroddu, MA

Costa, M

机构：

[1] NYU, Sch Med, Dept Environm Med, New York, NY 10016 USA

[2] NYU, Sch Med, Dept Pathol, New York, NY 10016 USA

[3] Univ Sassari, I-07100 Sassari, Sardinia, Italy

来源：

TOXICOLOGY LETTERS | 2002年 / 127卷 / 1-3期

关键词：

chromosome damage; heterochromatin; gene silencing; nickel;

D O I：

10.1016/S0378-4274(01)00485-4

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Humans are exposed to carcinogenic nickel (Ni) compounds both occupationally and environmentally. In this paper, molecular mechanisms of nickel carcinogenesis are considered from the point-of-view of the uptake of nickel sulfide particles in cells, their dissolution and their effects on heterochromatin. Molecular mechanisms by which nickel induces gene silencing, DNA hypermethylation and inhibition of histone acetylation, will be discussed. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：69 / 75

页数：7

共 27 条

[1] CYTOPLASMIC DISSOLUTION OF PHAGOCYTIZED CRYSTALLINE NICKEL SULFIDE PARTICLES - A PREREQUISITE FOR NUCLEAR UPTAKE OF NICKEL [J].