Breathing control center neurons that promote arousal in mice

被引：163

作者：

Yackle, Kevin ^{[1
,6
]}

Schwarz, Lindsay A. ^{[2
,7
]}

Kam, Kaiwen ^{[3
,4
]}

Sorokin, Jordan M. ^{[5
]}

Huguenard, John R. ^{[5
]}

Feldman, Jack L. ^{[3
]}

Luo, Liqun ^{[2
]}

Krasnow, Mark A. ^{[1
]}

机构：

[1] Stanford Univ, Dept Biochem, Sch Med, Howard Hughes Med Inst, Stanford, CA 94305 USA

[2] Stanford Univ, Howard Hughes Med Inst, Dept Biol, Stanford, CA 94305 USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Syst Neurobiol Lab, Los Angeles, CA 90095 USA

[4] Rosalind Franklin Univ Med & Sci, Chicago Med Sch, Dept Cell Biol & Anat, N Chicago, IL 60064 USA

[5] Stanford Univ, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA

[6] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94158 USA

[7] St Jude Childrens Res Hosp, Dept Dev Neurobiol, 332 N Lauderdale St, Memphis, TN 38105 USA

来源：

SCIENCE | 2017年 / 355卷 / 6332期

关键词：

COERULEUS-NORADRENERGIC SYSTEM; PRE-BOTZINGER COMPLEX; PREBOTZINGER COMPLEX; RESPIRATORY NEURONS; PANIC DISORDER; SPINAL-CORD; MODULATION; RHYTHM; ANXIETY; STRESS;

D O I：

10.1126/science.aai7984

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Slow, controlled breathing has been used for centuries to promote mental calming, and it is used clinically to suppress excessive arousal such as panic attacks. However, the physiological and neural basis of the relationship between breathing and higher-order brain activity is unknown. We found a neuronal subpopulation in the mouse preBotzinger complex (preBotC), the primary breathing rhythm generator, which regulates the balance between calm and arousal behaviors. Conditional, bilateral genetic ablation of the similar to 175 Cdh9/Dbx1 double-positive preBotC neurons in adult mice left breathing intact but increased calm behaviors and decreased time in aroused states. These neurons project to, synapse on, and positively regulate noradrenergic neurons in the locus coeruleus, a brain center implicated in attention, arousal, and panic that projects throughout the brain.

引用

页码：1411 / 1415

页数：5

共 28 条

[1] The locus coeruleus-noradrenergic system: modulation of behavioral state and state-dependent cognitive processes [J].

Berridge, CW ;

Waterhouse, BD .

BRAIN RESEARCH REVIEWS, 2003, 42 (01) :33-84

[2] Hindbrain interneurons and axon guidance signaling critical for breathing [J].

Bouvier, Julien ;

Thoby-Brisson, Muriel ;

Renier, Nicolas ;

Dubreuil, Veronique ;

Ericson, Johan ;

Champagnat, Jean ;

Pierani, Alessandra ;

Chedotal, Alain ;

Fortin, Gilles .

NATURE NEUROSCIENCE, 2010, 13 (09) :1066-U55

[3] Yoga Breathing, Meditation, and Longevity [J].

Brown, Richard P. ;

Gerbarg, Patricia L. .

LONGEVITY, REGENERATION, AND OPTIMAL HEALTH: INTEGRATING EASTERN AND WESTEN PERSPECTIVES, 2009, 1172 :54-62

[4] Sudarshan Kriya yogic breathing in the treatment of stress, anxiety, and depression:: Part II -: Clinical applications and guidelines [J].

Brown, RP ;

Gerbarg, PL .

JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE, 2005, 11 (04) :711-717

[5] RESPIRATORY-ASSOCIATED RHYTHMIC FIRING OF MIDBRAIN NEURONS IN CATS - RELATION TO LEVEL OF RESPIRATORY DRIVE [J].

CHEN, Z ;

ELDRIDGE, FL ;

WAGNER, PG .

JOURNAL OF PHYSIOLOGY-LONDON, 1991, 437 :305-325

[6] A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo [J].

Diez-Roux, Graciana ;

Banfi, Sandro ;

Sultan, Marc ;

Geffers, Lars ;

Anand, Santosh ;

Rozado, David ;

Magen, Alon ;

Canidio, Elena ;

Pagani, Massimiliano ;

Peluso, Ivana ;

Lin-Marq, Nathalie ;

Koch, Muriel ;

Bilio, Marchesa ;

Cantiello, Immacolata ;

Verde, Roberta ;

De Masi, Cristian ;

Bianchi, Salvatore A. ;

Cicchini, Juliette ;

Perroud, Elodie ;

Mehmeti, Shprese ;

Dagand, Emilie ;

Schrinner, Sabine ;

Nuernberger, Asja ;

Schmidt, Katja ;

Metz, Katja ;

Zwingmann, Christina ;

Brieske, Norbert ;

Springer, Cindy ;

Hernandez, Ana Martinez ;

Herzog, Sarah ;

Grabbe, Frauke ;

Sieverding, Cornelia ;

Fischer, Barbara ;

Schrader, Kathrin ;

Brockmeyer, Maren ;

Dettmer, Sarah ;

Helbig, Christin ;

Alunni, Violaine ;

Battaini, Marie-Annick ;

Mura, Carole ;

Henrichsen, Charlotte N. ;

Garcia-Lopez, Raquel ;

Echevarria, Diego ;

Puelles, Eduardo ;

Garcia-Calero, Elena ;

Kruse, Stefan ;

Uhr, Markus ;

Kauck, Christine ;

Feng, Guangjie ;

Milyaev, Nestor .

PLOS BIOLOGY, 2011, 9 (01)

[7] Understanding the Rhythm of Breathing: So Near, Yet So Far [J].

Feldman, Jack L. ;

Del Negro, Christopher A. ;

Gray, Paul A. .

ANNUAL REVIEW OF PHYSIOLOGY, VOL 75, 2013, 75 :423-452

[8] ADENOSINE STIMULATION, VENTILATION, AND AROUSAL FROM SLEEP [J].

GLEESON, K ;

ZWILLICH, CW .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1992, 145 (02) :453-457

[9] Modulation of respiratory frequency by peptidergic input to rhythmogenic neurons in the PreBotzinger complex [J].

Gray, PA ;

Rekling, JC ;

Bocchiaro, CM ;

Feldman, JL .

SCIENCE, 1999, 286 (5444) :1566-1568

[10] Developmental Origin of PreBotzinger Complex Respiratory Neurons [J].

Gray, Paul A. ;

Hayes, John A. ;

Ling, Guang Y. ;

Llona, Isabel ;

Tupal, Srinivasan ;

Picardo, Maria Cristina D. ;

Ross, Sarah E. ;

Hirata, Tsutomu ;

Corbin, Joshua G. ;

Eugenin, Jaime ;

Del Negro, Christopher A. .

JOURNAL OF NEUROSCIENCE, 2010, 30 (44) :14883-14895

← 1 2 3 →