The Influence of Temporal Resolution in Determining Pharmacokinetic Parameters From DCE-MRI Data

被引：63

作者：

Heisen, Marieke ^{[1
]}

Fan, Xiaobing ^{[2
]}

Buurman, Johannes ^{[3
]}

van Riel, Natal A. W.

Karczmar, Gregory S. ^{[2
]}

Romeny, Bart M. ter Haar

机构：

[1] Eindhoven Univ Technol, Dept Biomed Engn, Sect Biomed Image Anal, NL-5600 MB Eindhoven, Netherlands

[2] Univ Chicago, Dept Radiol, Chicago, IL 60637 USA

[3] Philips Healthcare, Healthcare Informat, Best, Netherlands

来源：

MAGNETIC RESONANCE IN MEDICINE | 2010年 / 63卷 / 03期

关键词：

DCE-MRI; temporal resolution; k-space data; pharmacokinetic model; downsampling; CONTRAST-ENHANCED MRI; T-1-WEIGHTED MRI; BREAST; TRACER; TUMORS;

D O I：

10.1002/mrm.22171

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

We investigated the influence of the temporal resolution of dynamic contrast-enhanced MRI data on pharmacokinetic parameter estimation. Dynamic Gd-DTPA (Gadolinium-diethylene triamine pentaacetic acid) enhanced MRI data of implanted prostate tumors on rat hind limb were acquired at 4.7 T, with a temporal resolution of similar to 5 sec. The data were subsequently downsampled to temporal resolutions in the range of 15 sec to 85 sec, using a strategy that involves a recombination of k-space data. A basic two-compartment model was fit to the contrast agent uptake curves. The results demonstrated that as temporal resolution decreases, the volume transfer constant (K(trans)) is progressively underestimated (similar to 4% to similar to 25%), and the fractional extravascular extracellular space (v(e)) is progressively overestimated (similar to 1% to similar to 10%). The proposed downsampling strategy simulates the influence of temporal resolution more realistically than simply downsampling by removing samples. Magn Reson Med 63:811-816, 2010. (C) 2010 Wiley-Liss, Inc.

引用

页码：811 / 816

页数：6