Treatment of Graves' ophthalmopathy

被引：20

作者：

Gonzalez-Garcia, Andres ^{[1
]}

Sales-Sanz, Marco ^{[2
]}

机构：

[1] Hosp Univ Ramon & Cajal, Unidad Enfermedades Sistem Autoinmunes & Minorita, Serv Med Interna, IRYCIS, Madrid, Spain

[2] Hosp Univ Ramon & Cajal, CSUR Tumores Orbitarios & Cirugia Descompres Orbi, IRYCIS, Serv Oftalmol, Madrid, Spain

来源：

MEDICINA CLINICA | 2021年 / 156卷 / 04期

关键词：

Graves-Basedow disease; Graves? ophthalmopathy; Orbitopathy; Glucocorticoids; Teprotumumab; Rituximab; Tocilizumab; QUALITY-OF-LIFE; INTRAVENOUS METHYLPREDNISOLONE; ORBITAL RADIOTHERAPY; ACTIVE MODERATE; ORBITOPATHY; THERAPY; MANAGEMENT; EFFICACY; DISEASE; SAFETY;

D O I：

10.1016/j.medcli.2020.07.031

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Graves' ophthalmopathy is an inflammatory disease with primary involvement of the extraocular muscles and the orbit. It encompasses the most common extra-thyroid manifestation in patients with GravesBasedow disease. The underlying cause is molecular mimicry with the TSH receptor in ocular fibroblasts, leading to an immuno-mediated pathogenesis. Glucocorticoids at high doses are the cornerstone in moderate-severe cases. However, some patients are corticorresistant or intolerant. In recent years, therapeutic novelties have been described in terms of the dosage of the immunosuppressive treatments used, as well as the emergence of biological therapy in this field. The objective of this review is to update the treatment of Graves' ophthalmopathy, as well as to present alternative options in patients resistant or intolerant to glucocorticoids. (c) 2020 Elsevier Espa & ntilde;a, S.L.U. All rights reserved.

引用

页码：180 / 186

页数：7

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