VHL takes HIF's breath away

被引：49
作者：
Krek, W [1 ]
机构：
[1] Friedrich Miescher Inst, CH-4058 Basel, Switzerland
来源：
NATURE CELL BIOLOGY | 2000年 / 2卷 / 07期
关键词：
D O I：
10.1038/35017129
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Inactivation of the von Hippel-Lindau (VHL) tumour-suppressor protein (pVHL) is associated with the von Hippel-Lindau cancer syndrome and the majority of kidney cancers. New evidence suggests that pVHL has properties of an F-box protein that targets the alpha-subunits of hypoxia-inducible factor (HIF)-1 for oxygen-dependent ubiquitination.
引用
收藏
页码：E121 / E123
页数：3
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