共 48 条
MLL-AF9-Induced Leukemogenesis Requires Coexpression of the Wild-Type Mll Allele
被引:196
作者:

Thiel, Austin T.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Dept Canc Biol, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA Univ Penn, Dept Canc Biol, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA

Blessington, Peter
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Dept Canc Biol, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA Univ Penn, Dept Canc Biol, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA

Zou, Tao
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Abramson Family Canc Res Inst, Dept Chem,Dept Bioengn, Dept Med,Dept Pathol & Lab Med, Philadelphia, PA 19104 USA Univ Penn, Dept Canc Biol, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA

Feather, Danielle
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Dept Canc Biol, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA Univ Penn, Dept Canc Biol, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA

Wu, Xinjiang
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Dept Canc Biol, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA Univ Penn, Dept Canc Biol, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA

Yan, Jizhou
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Dept Canc Biol, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA Univ Penn, Dept Canc Biol, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA

Zhang, Hui
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Dept Canc Biol, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA Univ Penn, Dept Canc Biol, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA

Liu, Zuguo
论文数: 0 引用数: 0
h-index: 0
机构:
Xiamen Univ, Inst Eye, Xiamen 361005, Fujian, Peoples R China
Xiamen Univ, Affiliated Xiamen Eye Ctr, Xiamen 361005, Fujian, Peoples R China Univ Penn, Dept Canc Biol, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA

Ernst, Patricia
论文数: 0 引用数: 0
h-index: 0
机构:
Dartmouth Med Sch, Dept Genet, Hanover, NH 03755 USA
Dartmouth Med Sch, Norris Cotton Canc Ctr, Hanover, NH 03755 USA Univ Penn, Dept Canc Biol, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA

Koretzky, Gary A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Abramson Family Canc Res Inst, Dept Chem,Dept Bioengn, Dept Med,Dept Pathol & Lab Med, Philadelphia, PA 19104 USA Univ Penn, Dept Canc Biol, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA

Hua, Xianxin
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Penn, Dept Canc Biol, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA Univ Penn, Dept Canc Biol, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA
机构:
[1] Univ Penn, Dept Canc Biol, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA
[2] Univ Penn, Abramson Family Canc Res Inst, Dept Chem,Dept Bioengn, Dept Med,Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
[3] Xiamen Univ, Inst Eye, Xiamen 361005, Fujian, Peoples R China
[4] Xiamen Univ, Affiliated Xiamen Eye Ctr, Xiamen 361005, Fujian, Peoples R China
[5] Dartmouth Med Sch, Dept Genet, Hanover, NH 03755 USA
[6] Dartmouth Med Sch, Norris Cotton Canc Ctr, Hanover, NH 03755 USA
来源:
基金:
美国国家卫生研究院;
关键词:
PARTIAL TANDEM DUPLICATION;
MIXED-LINEAGE LEUKEMIA;
TUMOR-SUPPRESSOR MENIN;
ACUTE MYELOID-LEUKEMIA;
HISTONE METHYLTRANSFERASE;
TRANSCRIPTIONAL ELONGATION;
H3K79;
METHYLATION;
GENE-EXPRESSION;
PHD FINGER;
STEM-CELLS;
D O I:
10.1016/j.ccr.2009.12.034
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Oncogenic fusion proteins are capable of initiating tumorigenesis, but the role of their wild-type counterparts in this process is poorly understood. The mixed lineage leukemia (MLL) gene undergoes chromosomal translocations, resulting in the formation of oncogenic MILL fusion proteins (MLL-FPs). Here, we show that menin recruits both wild-type MLL and oncogenic MLL-AF9 fusion protein to the loci of HOX genes to activate their transcription. Wild-type MLL not only catalyzes histone methylation at key target genes but also controls distinct MLL-AF9-induced histone methylation. Notably, the wild-type MY allele is required for MLL-AF9-induced leukemogenesis and maintenance of MLL-AF9-transformed cells. These findings suggest an essential cooperation between an oncogene and its wild-type counterpart in MLL-AF9-induced leukemogenesis.
引用
收藏
页码:148 / 159
页数:12
相关论文
共 48 条
[1]
MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia
[J].
Armstrong, SA
;
Staunton, JE
;
Silverman, LB
;
Pieters, R
;
de Boer, ML
;
Minden, MD
;
Sallan, SE
;
Lander, ES
;
Golub, TR
;
Korsmeyer, SJ
.
NATURE GENETICS,
2002, 30 (01)
:41-47

Armstrong, SA
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA

Staunton, JE
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA

Silverman, LB
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA

Pieters, R
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA

de Boer, ML
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA

Minden, MD
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA

Sallan, SE
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA

Lander, ES
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA

Golub, TR
论文数: 0 引用数: 0
h-index: 0
机构: Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA

Korsmeyer, SJ
论文数: 0 引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA
[2]
Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9
[J].
Ayton, PM
;
Cleary, ML
.
GENES & DEVELOPMENT,
2003, 17 (18)
:2298-2307

Ayton, PM
论文数: 0 引用数: 0
h-index: 0
机构:
Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA

Cleary, ML
论文数: 0 引用数: 0
h-index: 0
机构:
Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA
[3]
Modeling the initiation and progression of human acute leukemia in mice
[J].
Barabe, Frederic
;
Kennedy, James A.
;
Hope, Kristin J.
;
Dick, John E.
.
SCIENCE,
2007, 316 (5824)
:600-604

Barabe, Frederic
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hlth Network, Div Cell & Mol Biol, Toronto, ON M5G 1L7, Canada

Kennedy, James A.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hlth Network, Div Cell & Mol Biol, Toronto, ON M5G 1L7, Canada

Hope, Kristin J.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hlth Network, Div Cell & Mol Biol, Toronto, ON M5G 1L7, Canada

Dick, John E.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hlth Network, Div Cell & Mol Biol, Toronto, ON M5G 1L7, Canada Univ Hlth Network, Div Cell & Mol Biol, Toronto, ON M5G 1L7, Canada
[4]
The complex language of chromatin regulation during transcription
[J].
Berger, Shelley L.
.
NATURE,
2007, 447 (7143)
:407-412

Berger, Shelley L.
论文数: 0 引用数: 0
h-index: 0
机构:
Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA
[5]
The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling
[J].
Bitoun, Emmanuelle
;
Oliver, Peter L.
;
Davies, Kay E.
.
HUMAN MOLECULAR GENETICS,
2007, 16 (01)
:92-106

论文数: 引用数:
h-index:
机构:

Oliver, Peter L.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Oxford, Dept Physiol Anat & Genet, MRC, Funct Genet Unit, Oxford OX1 3QX, England Univ Oxford, Dept Physiol Anat & Genet, MRC, Funct Genet Unit, Oxford OX1 3QX, England

Davies, Kay E.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Oxford, Dept Physiol Anat & Genet, MRC, Funct Genet Unit, Oxford OX1 3QX, England Univ Oxford, Dept Physiol Anat & Genet, MRC, Funct Genet Unit, Oxford OX1 3QX, England
[6]
Malignant transformation initiated by MII-AF9: Gene dosage and critical target cells
[J].
Chen, Weili
;
Kumar, Ashish R.
;
Hudson, Wendy A.
;
Li, Quanzhi
;
Wu, Baolin
;
Staggs, Rodney A.
;
Lund, Erik A.
;
Sam, Thien N.
;
Kersey, John H.
.
CANCER CELL,
2008, 13 (05)
:432-440

Chen, Weili
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Minnesota, Ctr Canc, Minneapolis, MN 55455 USA Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA

Kumar, Ashish R.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA
Univ Minnesota, Ctr Canc, Minneapolis, MN 55455 USA Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA

Hudson, Wendy A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Minnesota, Ctr Canc, Minneapolis, MN 55455 USA Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA

Li, Quanzhi
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Minnesota, Ctr Canc, Minneapolis, MN 55455 USA Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA

Wu, Baolin
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Minnesota, Sch Publ Hlth, Div Biostat, Minneapolis, MN 55455 USA Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA

Staggs, Rodney A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Minnesota, Ctr Canc, Minneapolis, MN 55455 USA Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA

Lund, Erik A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Minnesota, Ctr Canc, Minneapolis, MN 55455 USA Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA

Sam, Thien N.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Minnesota, Ctr Canc, Minneapolis, MN 55455 USA Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA

Kersey, John H.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA
Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA
Univ Minnesota, Ctr Canc, Minneapolis, MN 55455 USA Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA
[7]
The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression
[J].
Chen, YX
;
Yan, JZ
;
Keeshan, K
;
Tubbs, AT
;
Wang, HR
;
Silva, A
;
Brown, EJ
;
Hess, JL
;
Pear, WS
;
Hua, XX
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2006, 103 (04)
:1018-1023

Chen, YX
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Dept Canc Biol, Abramson Family Canc Res Inst, Abramson Canc Ctr, Philadelphia, PA 19104 USA

Yan, JZ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Dept Canc Biol, Abramson Family Canc Res Inst, Abramson Canc Ctr, Philadelphia, PA 19104 USA

Keeshan, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Dept Canc Biol, Abramson Family Canc Res Inst, Abramson Canc Ctr, Philadelphia, PA 19104 USA

Tubbs, AT
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Dept Canc Biol, Abramson Family Canc Res Inst, Abramson Canc Ctr, Philadelphia, PA 19104 USA

Wang, HR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Dept Canc Biol, Abramson Family Canc Res Inst, Abramson Canc Ctr, Philadelphia, PA 19104 USA

Silva, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Dept Canc Biol, Abramson Family Canc Res Inst, Abramson Canc Ctr, Philadelphia, PA 19104 USA

Brown, EJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Dept Canc Biol, Abramson Family Canc Res Inst, Abramson Canc Ctr, Philadelphia, PA 19104 USA

Hess, JL
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Dept Canc Biol, Abramson Family Canc Res Inst, Abramson Canc Ctr, Philadelphia, PA 19104 USA

Pear, WS
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Dept Canc Biol, Abramson Family Canc Res Inst, Abramson Canc Ctr, Philadelphia, PA 19104 USA

Hua, XX
论文数: 0 引用数: 0
h-index: 0
机构: Univ Penn, Dept Canc Biol, Abramson Family Canc Res Inst, Abramson Canc Ctr, Philadelphia, PA 19104 USA
[8]
The Mll partial tandem duplication:: differential, tissue-specific activity in the presence or absence of the wild-type allele
[J].
Dorrance, Adrienne M.
;
Liu, Shujun
;
Chong, Anita
;
Pulley, Benjamin
;
Nemer, David
;
Guimond, Martin
;
Yuan, Weifeng
;
Chang, Dennis
;
Whitman, Susan P.
;
Marcucci, Guido
;
Caligiuri, Michael A.
.
BLOOD,
2008, 112 (06)
:2508-2511

Dorrance, Adrienne M.
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Dept Internal Med, Div Hematol & Oncol, Columbus, OH 43210 USA
Ohio State Univ, Dept Vet Biosci, Columbus, OH 43210 USA Ohio State Univ, Dept Internal Med, Div Hematol & Oncol, Columbus, OH 43210 USA

Liu, Shujun
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Dept Internal Med, Div Hematol & Oncol, Columbus, OH 43210 USA Ohio State Univ, Dept Internal Med, Div Hematol & Oncol, Columbus, OH 43210 USA

Chong, Anita
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Dept Internal Med, Div Hematol & Oncol, Columbus, OH 43210 USA Ohio State Univ, Dept Internal Med, Div Hematol & Oncol, Columbus, OH 43210 USA

Pulley, Benjamin
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Dept Internal Med, Div Hematol & Oncol, Columbus, OH 43210 USA Ohio State Univ, Dept Internal Med, Div Hematol & Oncol, Columbus, OH 43210 USA

Nemer, David
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Dept Internal Med, Div Hematol & Oncol, Columbus, OH 43210 USA Ohio State Univ, Dept Internal Med, Div Hematol & Oncol, Columbus, OH 43210 USA

Guimond, Martin
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Dept Internal Med, Div Hematol & Oncol, Columbus, OH 43210 USA Ohio State Univ, Dept Internal Med, Div Hematol & Oncol, Columbus, OH 43210 USA

Yuan, Weifeng
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Dept Internal Med, Div Hematol & Oncol, Columbus, OH 43210 USA Ohio State Univ, Dept Internal Med, Div Hematol & Oncol, Columbus, OH 43210 USA

Chang, Dennis
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Dept Internal Med, Div Hematol & Oncol, Columbus, OH 43210 USA Ohio State Univ, Dept Internal Med, Div Hematol & Oncol, Columbus, OH 43210 USA

Whitman, Susan P.
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Dept Internal Med, Div Hematol & Oncol, Columbus, OH 43210 USA
Ohio State Univ, Ctr Comprehens Canc, James Canc Hosp, Columbus, OH 43210 USA
Ohio State Univ, Solove Res Inst, Columbus, OH 43210 USA Ohio State Univ, Dept Internal Med, Div Hematol & Oncol, Columbus, OH 43210 USA

Marcucci, Guido
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Dept Internal Med, Div Hematol & Oncol, Columbus, OH 43210 USA
Ohio State Univ, Ctr Comprehens Canc, James Canc Hosp, Columbus, OH 43210 USA
Ohio State Univ, Solove Res Inst, Columbus, OH 43210 USA Ohio State Univ, Dept Internal Med, Div Hematol & Oncol, Columbus, OH 43210 USA

Caligiuri, Michael A.
论文数: 0 引用数: 0
h-index: 0
机构:
Ohio State Univ, Dept Internal Med, Div Hematol & Oncol, Columbus, OH 43210 USA
Ohio State Univ, Dept Vet Biosci, Columbus, OH 43210 USA
Ohio State Univ, Ctr Comprehens Canc, James Canc Hosp, Columbus, OH 43210 USA
Ohio State Univ, Solove Res Inst, Columbus, OH 43210 USA Ohio State Univ, Dept Internal Med, Div Hematol & Oncol, Columbus, OH 43210 USA
[9]
Double chromodomains cooperate to recognize the methylated histone H3 tail
[J].
Flanagan, JF
;
Mi, LZ
;
Chruszcz, M
;
Cymborowski, M
;
Clines, KL
;
Kim, YC
;
Minor, W
;
Rastinejad, F
;
Khorasanizadeh, S
.
NATURE,
2005, 438 (7071)
:1181-1185

Flanagan, JF
论文数: 0 引用数: 0
h-index: 0
机构: Univ Virginia Hlth Syst, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA

Mi, LZ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Virginia Hlth Syst, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA

Chruszcz, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Virginia Hlth Syst, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA

Cymborowski, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Virginia Hlth Syst, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA

Clines, KL
论文数: 0 引用数: 0
h-index: 0
机构: Univ Virginia Hlth Syst, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA

Kim, YC
论文数: 0 引用数: 0
h-index: 0
机构: Univ Virginia Hlth Syst, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA

Minor, W
论文数: 0 引用数: 0
h-index: 0
机构: Univ Virginia Hlth Syst, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA

Rastinejad, F
论文数: 0 引用数: 0
h-index: 0
机构: Univ Virginia Hlth Syst, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA

Khorasanizadeh, S
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Virginia Hlth Syst, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA Univ Virginia Hlth Syst, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA
[10]
Myc-binding-site recognition in the human genome is determined by chromatin context
[J].
Guccione, Ernesto
;
Martinato, Francesca
;
Finocchiaro, Giacomo
;
Luzi, Lucilla
;
Tizzoni, Laura
;
Dall'Olio, Valentina
;
Zardo, Giuseppe
;
Nervi, Clara
;
Bernard, Loris
;
Amati, Bruno
.
NATURE CELL BIOLOGY,
2006, 8 (07)
:764-U225

Guccione, Ernesto
论文数: 0 引用数: 0
h-index: 0
机构: European Inst Oncol, Dept Expt Oncol, I-20139 Milan, Italy

Martinato, Francesca
论文数: 0 引用数: 0
h-index: 0
机构: European Inst Oncol, Dept Expt Oncol, I-20139 Milan, Italy

Finocchiaro, Giacomo
论文数: 0 引用数: 0
h-index: 0
机构: European Inst Oncol, Dept Expt Oncol, I-20139 Milan, Italy

论文数: 引用数:
h-index:
机构:

Tizzoni, Laura
论文数: 0 引用数: 0
h-index: 0
机构: European Inst Oncol, Dept Expt Oncol, I-20139 Milan, Italy

Dall'Olio, Valentina
论文数: 0 引用数: 0
h-index: 0
机构: European Inst Oncol, Dept Expt Oncol, I-20139 Milan, Italy

Zardo, Giuseppe
论文数: 0 引用数: 0
h-index: 0
机构: European Inst Oncol, Dept Expt Oncol, I-20139 Milan, Italy

Nervi, Clara
论文数: 0 引用数: 0
h-index: 0
机构: European Inst Oncol, Dept Expt Oncol, I-20139 Milan, Italy

Bernard, Loris
论文数: 0 引用数: 0
h-index: 0
机构: European Inst Oncol, Dept Expt Oncol, I-20139 Milan, Italy

论文数: 引用数:
h-index:
机构: