The T-cell-specific adapter protein family: TSAd, ALX, and SH2D4A/SH2D4B

被引：16

作者：

Lapinski, Philip E. ^{[1
]}

Oliver, Jennifer A. ^{[1
]}

Bodie, Jennifer N. ^{[1
]}

Marti, Francesc ^{[1
]}

King, Philip D. ^{[1
]}

机构：

[1] Univ Michigan, Sch Med, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA

来源：

IMMUNOLOGICAL REVIEWS | 2009年 / 232卷

基金：

美国国家卫生研究院;

关键词：

adapter proteins; protein tyrosine kinases; signal transduction; T lymphocytes; autoimmunity; knockout mice; VALOSIN-CONTAINING PROTEIN; SRC HOMOLOGY-2 DOMAIN; ANTIGEN-RECEPTOR; NEGATIVE REGULATION; TYROSINE KINASE; SH2D2A GENE; GROWTH-FACTOR; CUTTING EDGE; LIPID RAFTS; SIGNAL-TRANSDUCTION;

D O I：

10.1111/j.1600-065X.2009.00829.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Adapter proteins play key roles in intracellular signal transduction through complex formation with catalytically active signaling molecules. In T lymphocytes, the role of several different types of adapter proteins in T-cell antigen receptor signal transduction is well established. An exception to this is the family of T-cell-specific adapter (TSAd) proteins comprising of TSAd, adapter protein of unknown function (ALX), SH2D4A, and SH2D4B. Only recently has the function of these adapters in T-cell signal transduction been explored. Here, we discuss advances in our understanding of the role of this family of adapter proteins in T cells. Their function as regulators of signal transduction in other cell types is also discussed.

引用

页码：240 / 254

页数：15

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