Rapid Effect of Benralizumab for Hypereosinophilia in a Case of Severe Asthma with Eosinophilic Chronic Rhinosinusitis

被引：12

作者：

Tsurumaki, Hiroaki ^{[1
]}

Matsuyama, Toshiyuki ^{[2
]}

Ezawa, Kazuma ^{[1
]}

Koga, Yasuhiko ^{[1
]}

Yatomi, Masakiyo ^{[1
]}

Aoki-Saito, Haruka ^{[1
]}

Chikamatsu, Kazuaki ^{[2
]}

Hisada, Takeshi ^{[3
]}

机构：

[1] Gunma Univ, Grad Sch Med, Dept Resp Med, Maebashi, Gunma 3718511, Japan

[2] Gunma Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Maebashi, Gunma 3718511, Japan

[3] Gunma Univ, Grad Sch Hlth Sci, Maebashi, Gunma 3718514, Japan

来源：

MEDICINA-LITHUANIA | 2019年 / 55卷 / 07期

基金：

日本学术振兴会;

关键词：

severe asthma; benralizumab; hypereosinophilia; bronchial thermoplasty; eosinophilic chronic rhinosinusitis; BRONCHIAL THERMOPLASTY; DOUBLE-BLIND; MEPOLIZUMAB; MULTICENTER; SAFETY;

D O I：

10.3390/medicina55070336

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 56-year-old man with severe asthma underwent bronchial thermoplasty (BT). However, his asthma exacerbated and hypereosinophilia developed 2 months later, thus necessitating oral corticosteroid (OCS) therapy. Six months after BT, a diagnosis of severe asthma with eosinophilic chronic rhinosinusitis (ECRS) was made and benralizumab treatment was initiated; the blood eosinophil count subsequently decreased and lung function improved, thereby permitting OCS dose tapering. Surprisingly, benralizumab both reduced nasal polyps and ameliorated ECRS. Thus, benralizumab may be a useful drug for the rapid treatment of severe asthma with ECRS, especially in patients with hypereosinophilia.

引用

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