Hexitol nucleic acids (HNA): Synthesis and properties

被引：9

作者：

DeBouvere, B ^{[1
]}

Kerremans, L ^{[1
]}

Hendrix, C ^{[1
]}

DeWinter, H ^{[1
]}

Schepers, G ^{[1
]}

VanAerschot, A ^{[1
]}

Herdewijn, P ^{[1
]}

机构：

[1] UNIV CATHOLIQUE LOUVAIN, REGA INST MED RES, B-3000 LOUVAIN LA NEUVE, BELGIUM

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 1997年 / 16卷 / 7-9期

关键词：

D O I：

10.1080/07328319708006119

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

While improved alkylation procedures have been worked out for the coupling of purine bases to the anhydrohexitol ring using sulphonate activating groups on the anhydrohexitol ring, the Mitsunobu reaction seems to be the method of choice for synthesis of the pyrimidine analogues. In a mixed sequence context, the anhydrohexitol oligonucleotides still display strong and very selective basepairing properties, with a strong preference for RNA as the complement.

引用

页码：973 / 976

页数：4

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