Optimization of stripline-based microfluidic chips for high-resolution NMR

被引：63
作者：
Bart, J. [1 ]
Janssen, J. W. G. [2 ]
van Bentum, P. J. M. [2 ]
Kentgens, A. P. M. [2 ]
Gardeniers, J. G. E. [1 ]
机构：
[1] Univ Twente, MESA Inst Nanotechnol, NL-7500 AE Enschede, Netherlands
[2] Radboud Univ Nijmegen, Inst Mol & Mat, NL-6525 ED Nijmegen, Netherlands
来源：
JOURNAL OF MAGNETIC RESONANCE | 2009年 / 201卷 / 02期
关键词：
Stripline; Microcoil; Microfluidic; Lab-on-a-chip; NUCLEAR-MAGNETIC-RESONANCE; HIGH-RESISTIVITY SILICON; H-1-NMR SPECTROSCOPY; ANALYSIS SYSTEMS; PROBE; MICROCOILS; SUBSTRATE; DESIGN;
D O I：
10.1016/j.jmr.2009.09.007
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
We here report on the optimization, fabrication and experimental characterization of a stripline-based microfluidic NMR probe, realized in a silicon substrate. The stripline geometry was modelled in respect of rf-homogeneity, sensitivity and spectral resolution. Using these models, optimal dimensional ratios were found, which hold for every sample size. Based on the optimized parameters, a simple integrated stripline-based microfluidic chip was realized. The fabrication of this chip is described in detail. We achieved a sensitivity of 0.47 nmol/root Hz and a resolution of 0.7 Hz. The rf-homlogeneity (A(810 degrees)/A(90 degrees).) was 76% and was proved to be suitable for 2D-NMR analysis of glucose. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：175 / 185
页数：11
相关论文
共 50 条
  • [31] Characterization of a high-resolution solid-state micropump that can be integrated into microfluidic systems
    Aaron R. Smith
    Andrey Saren
    Jari Järvinen
    Kari Ullakko
    Microfluidics and Nanofluidics, 2015, 18 : 1255 - 1263
  • [32] Automated Microfluidic Platform for Serial Polymerase Chain Reaction and High-Resolution Melting Analysis
    Cao, Weidong
    Bean, Brian
    Corey, Scott
    Coursey, Johnathan S.
    Hasson, Kenton C.
    Inoue, Hiroshi
    Isano, Taisuke
    Kanderian, Sami
    Lane, Ben
    Liang, Hongye
    Murphy, Brian
    Owen, Greg
    Shinoda, Nobuhiko
    Zeng, Shulin
    Knight, Ivor T.
    JALA, 2016, 21 (03): : 402 - 411
  • [33] Characterization of a high-resolution solid-state micropump that can be integrated into microfluidic systems
    Smith, Aaron R.
    Saren, Andrey
    Jarvinen, Jari
    Ullakko, Kari
    MICROFLUIDICS AND NANOFLUIDICS, 2015, 18 (5-6) : 1255 - 1263
  • [34] Selective high-resolution DNP-enhanced NMR of biomolecular binding sites
    Marin-Montesinos, Ildefonso
    Goyard, David
    Gillon, Emilie
    Renaudet, Olivier
    Imberty, Anne
    Hediger, Sabine
    De Paepe, Gael
    CHEMICAL SCIENCE, 2019, 10 (11) : 3366 - 3374
  • [35] High-resolution multi-dimensional NMR spectroscopy of proteins in human cells
    Inomata, Kohsuke
    Ohno, Ayako
    Tochio, Hidehito
    Isogai, Shin
    Tenno, Takeshi
    Nakase, Ikuhiko
    Takeuchi, Toshihide
    Futaki, Shiroh
    Ito, Yutaka
    Hiroaki, Hidekazu
    Shirakawa, Masahiro
    NATURE, 2009, 458 (7234) : 106 - U11
  • [36] Persistent-mode operation of a 920 MHz high-resolution NMR magnet
    Kiyoshi, T
    Sato, A
    Takeuchi, T
    Itoh, K
    Matsumoto, S
    Ozaki, O
    Fukushima, K
    Wada, H
    Yoshikawa, M
    Kamikado, T
    Ito, S
    Miki, T
    Hase, T
    Hamada, M
    Hayashi, S
    Kawate, Y
    Hirose, R
    IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY, 2002, 12 (01) : 711 - 714
  • [37] A new configuration of high-resolution NMR spectrometer with superconducting split-magnet
    Okada, Michiya
    Kitaguchi, Hitoshi
    IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY, 2008, 18 (02) : 878 - 881
  • [38] HIGH-RESOLUTION NMR AND RELAXOMETRIC STUDIES OF LN(III) COMPLEXES OF RELEVANCE TO MRI
    AIME, S
    BOTTA, M
    NONNATO, A
    TERRENO, E
    ANELLI, PL
    UGGERI, F
    JOURNAL OF ALLOYS AND COMPOUNDS, 1995, 225 (1-2) : 274 - 278
  • [39] Study of the sedge (Carex) lignin by high-resolution mass spectrometry and NMR spectroscopy
    Pikovskoi, I. I.
    Kosyakov, D. S.
    Faleva, A., V
    Shavrina, I. S.
    Kozhevnikov, A. Yu
    Ul'yanovskii, N., V
    RUSSIAN CHEMICAL BULLETIN, 2020, 69 (10) : 2004 - 2012
  • [40] Controlling the false discovery rate for feature selection in high-resolution NMR spectra
    Kim, Seoung Bum
    Chen, Victoria C. P.
    Park, Youngja
    Ziegler, Thomas R.
    Jones, Dean P.
    Statistical Analysis and Data Mining, 2008, 1 (02): : 57 - 66
12345