Synthesis and in vivo anti-inflammatory activity of long-chain 2-amino-alcohols

被引：12
|
作者：
Magrioti, V
Hadjipavlou-Litina, D
Constantinou-Kokotou, V
机构：
[1] Agr Univ Athens, Chem Labs, Athens 11855, Greece
[2] Aristotle Univ Thessaloniki, Dept Pharmaceut Chem, GR-54006 Thessaloniki, Greece
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 03期
关键词：
D O I：
10.1016/S0960-894X(02)00939-3
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis of optically pure long-chain 2-amino-alcohols and 1-O-dodecyl-2-deoxy-2-amino-sn-glyceroI was carried out starting from L- or D-Boc-Ser(OBn)-ol by oxidation and consecutive Wittig reaction or etherification reaction. 2-Amino-oleyl alcohol was synthesized by reduction of the corresponding 2-amino-oleic acid. All the long chain amino-alcohols presented interesting inhibition of carrageenin-induced paw edema in rats (ED50 from 0.017 to 0.010 mmol/kg). (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：375 / 377
页数：3
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