N-Trifluoromethylation of Nitrosoarenes with Sodium Triflinate

被引：42

作者：

van der Werf, Angela ^{[1
]}

Hribersek, Matic ^{[1
]}

Selander, Nicklas ^{[1
]}

机构：

[1] Stockholm Univ, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, Sweden

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 09期

基金：

瑞典研究理事会;

关键词：

FLUORINE; NITROSOBENZENES; TRIFLUOROMETHANESULFINATE; PHARMACEUTICALS; HYDROAMINATION; NITROSATION; ANNULATION; RADICALS; AMINES; ETHERS;

D O I：

10.1021/acs.orglett.7b00908

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly efficient N-trifluoromethylation of nitro-soarenes is reported. The inexpensive and convenient Langlois reagent (sodium triflinate) is employed as a Ch(3)-radical source in combination with a copper catalyst and an oxidant. N-Trifluoromethylated hychoxylamines are obtained in high yields within 1 h at room temperature. The addition of hydroquinone was found to be instrumental to prevent the formation of side products. The method is high-yielding is scalable, and displays a high functional group tolerance.

引用

页码：2374 / 2377

页数：4

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