Ecalectin/galectin-9, a novel eosinophil chemoattractant: Its function and production

被引：47
|
作者：
Hirashima, M [1 ]
机构：
[1] Kagawa Med Sch, Dept Immunol & Immunopathol, Kagawa 76107, Japan
来源：
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 2000年 / 122卷
关键词：
ecalectin; galectin; eosinophil; chemoattraction; regulation;
D O I：
10.1159/000053623
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
We have recently succeeded in purifying and cloning a novel eosinophil chemoattractant, ecalectin/galectin-9, which belong to a rapidly growing galectin family. The eosinophil chemoattractant activity of ecalectin is potent and selective for eosinophils. The cellular source of ecalectin has been thought to be antigen-stimulated T cells. Herein, we will review the significance of its divalent galactoside-binding activity in ecalectin-induced eosinophil chemoattraction and the regulation of ecalectin expression in immune cells. Copyright (C) 2000 S. Karger AG, Basel.
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收藏
页码：6 / 9
页数：4
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