Candida albicans vaginitis in a murine model is reduced by polypeptide-enriched Gastrodia elata extracts

被引：13

作者：

Cai, Xueying ^{[1
]}

Kong, Fange ^{[1
]}

Wang, Ruochen ^{[1
]}

Zhai, Siyu ^{[1
]}

Guan, Xin ^{[2
]}

Zhang, Guirong ^{[1
]}

Wang, Di ^{[1
]}

机构：

[1] Jilin Univ, Sch Life Sci, Changchun 130012, Jilin, Peoples R China

[2] Jilin Univ, Coll Basic Med Sci, Dept Pharmacol, Changchun 130006, Jilin, Peoples R China

来源：

FUTURE MICROBIOLOGY | 2019年 / 14卷 / 10期

关键词：

antifungal activity; Candida albicans; inflammation; Lactobacillus; polypeptide-enriched Gastrodia elata extracts; vulvovaginal candidiasis; BRAIN;

D O I：

10.2217/fmb-2018-0299

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Aim: The primary objective of this study was to evaluate the effects of polypeptide-enriched Gastrodia elata extracts (GE) on vulvovaginal candidiasis (VVC). Materials & methods: A VVC model induced by Candida albicans (C. albicans) infection was successfully developed in BALB/c mice. After treatment, the colony forming unit (CFU) of vaginal lavage was measured by plating. The extent of the inflammatory response was assessed by hematoxylin-eosin (H&E) staining and enzyme-linked immunosorbent assay (ELISA). Results: GE had an inhibitory effect on the proliferation of C. albicans and inflammatory reaction. Meanwhile, it had a potentially beneficial effect on the growth of Lactobacillus. Conclusion: These results showed the potential application of GE as an antifungal agent in VVC treatment.

引用

页码：839 / 846

页数：8

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