Candida albicans vaginitis in a murine model is reduced by polypeptide-enriched Gastrodia elata extracts

被引：12
作者：
Cai, Xueying [1 ]
Kong, Fange [1 ]
Wang, Ruochen [1 ]
Zhai, Siyu [1 ]
Guan, Xin [2 ]
Zhang, Guirong [1 ]
Wang, Di [1 ]
机构：
[1] Jilin Univ, Sch Life Sci, Changchun 130012, Jilin, Peoples R China
[2] Jilin Univ, Coll Basic Med Sci, Dept Pharmacol, Changchun 130006, Jilin, Peoples R China
来源：
FUTURE MICROBIOLOGY | 2019年 / 14卷 / 10期
关键词：
antifungal activity; Candida albicans; inflammation; Lactobacillus; polypeptide-enriched Gastrodia elata extracts; vulvovaginal candidiasis; BRAIN;
D O I：
10.2217/fmb-2018-0299
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Aim: The primary objective of this study was to evaluate the effects of polypeptide-enriched Gastrodia elata extracts (GE) on vulvovaginal candidiasis (VVC). Materials & methods: A VVC model induced by Candida albicans (C. albicans) infection was successfully developed in BALB/c mice. After treatment, the colony forming unit (CFU) of vaginal lavage was measured by plating. The extent of the inflammatory response was assessed by hematoxylin-eosin (H&E) staining and enzyme-linked immunosorbent assay (ELISA). Results: GE had an inhibitory effect on the proliferation of C. albicans and inflammatory reaction. Meanwhile, it had a potentially beneficial effect on the growth of Lactobacillus. Conclusion: These results showed the potential application of GE as an antifungal agent in VVC treatment.
引用
收藏
页码：839 / 846
页数：8
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