Rapid Development of Hypertension by Sorafenib: Toxicity or Target?

被引：46

作者：

Humphreys, Benjamin D. ^{[2
,3
]}

Atkins, Michael B. ^{[1
,4
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Div Hematol Oncol, Boston, MA 02115 USA

[2] Brigham & Womens Hosp, Div Renal, Boston, MA 02115 USA

[3] Dana Farber Canc Inst, Lance Armstrong Fdn Adult Survivorship Program, Boston, MA 02115 USA

[4] Dana Farber Harvard Canc Ctr, Kidney Canc Program, Boston, MA USA

来源：

CLINICAL CANCER RESEARCH | 2009年 / 15卷 / 19期

关键词：

ENDOTHELIAL GROWTH-FACTOR; ANGIOGENESIS; CANCER;

D O I：

10.1158/1078-0432.CCR-09-1717

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Blood pressure elevation is likely a pharmacodynamic marker of VEGF signaling pathway (VSP) inhibition and could be useful for optimizing safe and effective VSP inhibitor dosing. Blood pressure rises on the first day of treatment, facilitating design and interpretation of future trials aiming to correlate blood pressure changes with clinical outcomes. (Clin Cancer Res 2009;15(19):5947-9)

引用

页码：5947 / 5949

页数：3

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