Strategies to enhance efficacy of SPION-labeled stem cell homing by magnetic attraction: a systemic review with meta-analysis

被引:23
作者
Ahn, Ye Ji [1 ,2 ]
Kong, Tae Hoon [1 ,2 ]
Choi, Jin Sil [1 ,2 ]
Yun, Wan Su [3 ]
Key, Jaehong [3 ]
Seo, Young Joon [1 ,2 ]
机构
[1] Yonsei Univ, Res Inst Hearing Enhancement, Wonju Coll Med, Wonju, South Korea
[2] Yonsei Univ, Wonju Coll Med, Dept Otorhinolaryngol, 20 Ilsan Ro, Wonju 26426, Gangwon Do, South Korea
[3] Yonsei Univ, Dept Biomed Engn, Wonju, South Korea
来源
INTERNATIONAL JOURNAL OF NANOMEDICINE | 2019年 / 14卷
关键词
stem cells; homing; SPION; magnetic attraction; stem cell therapy; systematic review; MESENCHYMAL STROMAL CELLS; BONE-MARROW; MYOCARDIAL-INFARCTION; IN-VIVO; NANOPARTICLES; RESONANCE; DELIVERY; BRAIN; RETENTION; THERAPY;
D O I
10.2147/IJN.S204910
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Stem cells possess a promising potential in the clinical field. The application and effective delivery of stem cells to the desired target organ or site of injury plays an important role. This review describes strategies on understanding the effective delivery of stem cells labeled with superparamagnetic iron oxide nanoparticles (SPION) using an external magnet to enhance stem cell migration in vivo and in vitro. Fourteen total publications among 174 articles were selected. Stem cell type, SPION characteristics, labeling time, and magnetic force in vivo are considered important factors affecting the effective delivery of stem cells to the homing site. Most papers reported that the efficiency was increased when magnet is applied compared to those without. Ten studies analyzed the homing competency of SPION-labeled MSCs in vitro by observing the migration of the cell toward the external magnet. In cell-based experiments, the mechanism of magnetic attraction, the kind of nanoparticles, and various stem cells were studied well. Meta-analysis has shown the mean size of nanoparticles and degree of recovery or regeneration of damaged target organs upon in vivo studies. This strategy may provide a guideline for designing studies involving stem cell homing and further expand stem cell.
引用
收藏
页码:4849 / 4866
页数:18
相关论文
共 54 条
[1]   Therapeutics with SPION-labeled stem cells for the main diseases related to brain aging: a systematic review [J].
Alvarim, Larissa T. ;
Nucci, Leopoldo P. ;
Mamani, Javier B. ;
Marti, Luciana C. ;
Aguiar, Marina F. ;
Silva, Helio R. ;
Silva, Gisele S. ;
Nucci-da-Silva, Mariana P. ;
DelBel, Elaine A. ;
Gamarra, Lionel F. .
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2014, 9 :3749-3770
[2]   A model of lysosomal metabolism of dextran coated superparamagnetic iron oxide (SPIO) nanoparticles: implications for cellular magnetic resonance imaging [J].
Arbab, AS ;
Wilson, LB ;
Ashari, P ;
Jordan, EK ;
Lewis, BK ;
Frank, JA .
NMR IN BIOMEDICINE, 2005, 18 (06) :383-389
[3]   In vivo trafficking and targeted delivery of magnetically labeled stem cells [J].
Arbab, AS ;
Jordan, EK ;
Wilson, LB ;
Yocum, GT ;
Lewis, BK ;
Frank, JA .
HUMAN GENE THERAPY, 2004, 15 (04) :351-360
[4]   Turning brain into blood: A hematopoietic fate adopted by adult neural stem cells in vivo [J].
Bjornson, CRR ;
Rietze, RL ;
Reynolds, BA ;
Magli, MC ;
Vescovi, AL .
SCIENCE, 1999, 283 (5401) :534-537
[5]   Guidance of Stem Cells to a Target Destination in Vivo by Magnetic Nanoparticles in a Magnetic Field [J].
Chen, Jialong ;
Huang, Nan ;
Ma, Baolong ;
Maitz, Manfred F. ;
Wang, Juan ;
Li, Jingan ;
Li, Quanli ;
Zhao, Yuancong ;
Xiong, Kaiqin ;
Liu, Xin .
ACS APPLIED MATERIALS & INTERFACES, 2013, 5 (13) :5976-5985
[6]   Magnetic Enhancement of Cell Retention, Engraftment, and Functional Benefit After Intracoronary Delivery of Cardiac-Derived Stem Cells in a Rat Model of Ischemia/Reperfusion [J].
Cheng, Ke ;
Malliaras, Konstantinos ;
Li, Tao-Sheng ;
Sun, Baiming ;
Houde, Christiane ;
Galang, Giselle ;
Smith, Jeremy ;
Matsushita, Noriko ;
Marban, Eduardo .
CELL TRANSPLANTATION, 2012, 21 (06) :1121-1135
[7]   Advanced cell therapies: targeting, tracking and actuation of cells with magnetic particles [J].
Connell, John J. ;
Patrick, P. Stephen ;
Yu, Yichao ;
Lythgoe, Mark F. ;
Kalber, Tammy L. .
REGENERATIVE MEDICINE, 2015, 10 (06) :757-772
[8]   Regulated portals of entry into the cell [J].
Conner, SD ;
Schmid, SL .
NATURE, 2003, 422 (6927) :37-44
[9]   Homing and migration of mesenchymal stromal cells: How to improve the efficacy of cell therapy? [J].
De Becker, Ann ;
Van Riet, Ivan .
WORLD JOURNAL OF STEM CELLS, 2016, 8 (03) :73-87
[10]   Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into nonhuman primates [J].
Devine, SM ;
Cobbs, C ;
Jennings, M ;
Bartholomew, A ;
Hoffman, R .
BLOOD, 2003, 101 (08) :2999-3001