Family history of melanoma and Parkinson disease risk

被引:91
作者
Gao, X. [1 ,3 ]
Simon, K. C. [3 ]
Han, J. [1 ]
Schwarzschild, M. A. [4 ]
Ascherio, A. [1 ,2 ,3 ]
机构
[1] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA 02115 USA
[2] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
[3] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA
[4] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA
关键词
MALIGNANT-MELANOMA; CUTANEOUS MELANOMA; TOBACCO USE; CANCER; LEVODOPA; METAANALYSIS; INHIBITION; APOPTOSIS; SKIN;
D O I
10.1212/WNL.0b013e3181bd13a1
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Co-occurrence of Parkinson disease (PD) and melanoma has been reported in numerous studies. If this was due to common genetic mechanisms, a positive family history of melanoma would be associated with an excessive PD risk, independent of environmental risk factors for PD. Methods: We prospectively examined associations between a family history of melanoma and PD among 157,036 men and women free of PD at baseline (1990 for men and 1982 for women) who participated in 2 ongoing US cohorts: the Health Professional Follow-up Study and the Nurses' Health Study. Information on family history of melanoma in parents or siblings was assessed via questionnaire. Relative risks and 95% confidence intervals were estimated using Cox proportional hazards models and pooled using a fixed-effects model. Results: During 14-20 years follow-up, we identified 616 incident PD cases. A family history of melanoma in a first-degree relative was associated with a higher risk of PD (multivariate relative risk = 1.85; 95% confidence interval: 1.2, 2.8; p = 0.004), after adjusting for smoking, ethnicity, caffeine intake, and other covariates. In contrast, we did not observe significant associations between a family history of colorectal, lung, prostate, or breast cancer and PD risk. Interactions between melanoma family history and age, smoking, or caffeine intake were not significant and subgroup analyses according to these factors generated similar results. Conclusions: Our findings support the notion that melanoma and Parkinson disease (PD) share common genetic components. The genetic determinants of melanoma could therefore be explored as susceptibility candidate genes for PD. Neurology (R) 2009;73:1286-1291
引用
收藏
页码:1286 / 1291
页数:6
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