Editing streptomycete genomes in the CRISPR/Cas9 age

被引：65

作者：

Alberti, Fabrizio ^{[1
]}

Corre, Christophe ^{[1
]}

机构：

[1] Univ Warwick, Dept Chem, Sch Life Sci, Gibbet Hill Rd, Coventry CV4 7AL, W Midlands, England

来源：

NATURAL PRODUCT REPORTS | 2019年 / 36卷 / 09期

基金：

英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

SEQUENCE-SPECIFIC CONTROL; GENE-CLUSTER; POLYKETIDE SYNTHASE; BIOSYNTHESIS; DISCOVERY; CLONING; ENDONUCLEASE; DISRUPTION; DAPTOMYCIN; ACTIVATION;

D O I：

10.1039/c8np00081f

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Covering: up to December 2018 This article aims to highlight advantages, drawbacks and issues that users should consider when implementing the use of CRISPR/Cas9-tools for genome editing in streptomycetes, the most prolific source of antimicrobial natural products to date. Here, we examine four toolkits that have so far been made available for streptomycete in vivo-engineering and one for in vitro-editing, and review how they have been applied over the last three years. Our critical evaluation of these toolkits intends to support potential users in determining what they could achieve, what they should consider and what system they should select/optimise for their application.

引用

页码：1237 / 1248

页数：12

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