A novel gabapentin based intermolecular Ugi four-center, three-component reaction for preparing N-cyclohexyl-2-(3-oxo-2-azaspiro[4,5]decan-2-yl)-2-aryl acetamide derivatives

被引：7
|
作者：
Darehkordi, Ali [1 ]
Zand-Vakili, Fatemeh [1 ]
Rafsanjani, Alireza Talebizadeh [2 ]
机构：
[1] Vali E Asr Univ Rafsanjan, Dept Chem, Fac Sci, Rafsanjan 77176, Iran
[2] Vali E Asr Univ Rafsanjan, Dept Chem Engn, Fac Engn, Rafsanjan 77176, Iran
来源：
TETRAHEDRON LETTERS | 2016年 / 57卷 / 04期
关键词：
Gabapentin; N-Cyclohexyl-2-(3-oxo-2-azaspiro[4,5]decan-2-yl)-2-aryl acetamide; Intermolecular Ugi; Four-center;
D O I：
10.1016/j.tetlet.2015.12.079
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An intermolecular Ugi reaction of 2-(1-(aminomethyl)cyclohexyl)acetic acid (gabapentin) with aromatic aldehydes and cyclohexyl isocyanide under mild conditions in ethanol has been developed to produce a novel class of N-cyclohexyl-2-(3-oxo-2-azaspiro[4,5]decan-2-yl)-2-aryl acetamides in good to excellent yields. This represents the first Letter for the intermolecular Ugi three component reactions of gabapentin, aromatic aldehydes, and an isocyanide. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：498 / 501
页数：4
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