Gene expression changes in tumor free tongue tissue adjacent to tongue squamous cell carcinoma

被引：32

作者：

Boldrup, Linda ^{[1
]}

Gu, Xiaolian ^{[1
]}

Coates, Philip J. ^{[2
]}

Norberg-Spaak, Lena ^{[3
]}

Fahraeus, Robin ^{[1
,2
,4
]}

Laurell, Goran ^{[3
,5
]}

Wilms, Torben ^{[3
]}

Nylander, Karin ^{[1
]}

机构：

[1] Umea Univ, Dept Med Biosci Pathol, SE-90185 Umea, Sweden

[2] Masaryk Mem Canc Inst, RECAMO, Brno 65653, Czech Republic

[3] Umea Univ, Dept Clin Sci ENT, SE-90185 Umea, Sweden

[4] Univ Paris 07, Hop St Louis, Inst Genet Mol, F-75010 Paris, France

[5] Uppsala Univ, Dept Surg Sci ENT, S-75236 Uppsala, Sweden

来源：

ONCOTARGET | 2017年 / 8卷 / 12期

关键词：

tongue cancer; RNA expression; field cancerization; CANCER; APOPTOSIS; HEAD; MUC1; INTERACTS; FEATURES; P63;

D O I：

10.18632/oncotarget.14288

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Due to the high frequency of loco-regional recurrences, which could be explained by changes in the field surrounding the tumor, patients with squamous cell carcinoma of head and neck show poor survival. Here we identified a total of 554 genes as dysregulated in clinically tumor free tongue tissue in patients with tongue tumors when compared to healthy control tongue tissue. Among the top dysregulated genes when comparing control and tumor free tissue were those involved in apoptosis (CIDEC, MUC1, ZBTB16, PRNP, ECT2), immune response (IFI27) and differentiation (KRT36). Data suggest that these are important findings which can aid in earlier diagnosis of tumor development, a relapse or a novel squamous cell carcinoma of the tongue, in the absence of histological signs of a tumor.

引用

页码：19389 / 19402

页数：14

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