In vitro antifungal activity of 2-(2'-hydroxy-5'-aminophenyl)benzoxazole in Candida spp. strains

被引：7

作者：

Daboit, Tatiane Caroline ^{[2
]}

Ottonelli Stopiglia, Cheila Denise ^{[2
]}

Carissimi, Mariana ^{[3
]}

Corbellini, Valeriano Antonio ^{[4
]}

Stefani, Valter ^{[5
]}

Scroferneker, Maria Lucia ^{[1
,2
]}

机构：

[1] Univ Fed Rio Grande do Sul, Inst Basic Hlth Sci, Dept Microbiol, BR-90420111 Porto Alegre, RS, Brazil

[2] Univ Fed Rio Grande do Sul, Postgrad Program Med, BR-90420111 Porto Alegre, RS, Brazil

[3] Municipal Dept Environm Protect, Caxias Do Sul, RS, Brazil

[4] Univ Santa Cruz Do Sul, Dept Chem & Phys, Santa Cruz Do Sul, RS, Brazil

[5] Univ Fed Rio Grande do Sul, Dept Organ Chem, BR-90420111 Porto Alegre, RS, Brazil

来源：

MYCOSES | 2009年 / 52卷 / 06期

关键词：

2-(2'-hydroxy-5'-aminophenyl)benzoxazole; benzoxazoles; Candida spp; antifungal activity; BIOLOGICAL EVALUATION; RAVUCONAZOLE; SUSCEPTIBILITY; ANTICANCER; RESISTANCE; VORICONAZOLE; DERIVATIVES; CASPOFUNGIN; ALBICANS; AGENTS;

D O I：

10.1111/j.1439-0507.2008.01638.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

P>The development of azole antifungals has allowed for the treatment of several fungal infections. However, the use of these compounds is restricted because of their hepatotoxicity or because they need to be administered together with other drugs in order to prevent resistance to monotherapy. Benzoxazole derivatives are among the most thriving molecular prototypes for the development of antifungal agents. 2-(2'-hydroxyphenyl) benzoxazoles are versatile molecules that emit fluorescence and have antibacterial, antiviral and antifungal properties. 2-(2'-hydroxy-5'-aminophenyl) benzoxazole (HAMBO) was tested against Candida yeast. The inhibition provided by HAMBO was lower than that of fluconazole, showing low antifungal activity against Candida spp., but equivalent to that of benzoxazoles tested in similar studies. HAMBO showed fungistatic activity against all analysed strains. This class of novel benzoxazole compounds may be used as template to produce better antifungal drugs.

引用

页码：507 / 510

页数：4

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