STEM CELL THERAPIES, GENE-BASED THERAPIES, OPTOGENETICS, AND RETINAL PROSTHETICS: CURRENT STATE AND IMPLICATIONS FOR THE FUTURE

被引：23

作者：

Wood, Edward H. ^{[1
]}

Tang, Peter H. ^{[2
]}

De la Huerta, Irina ^{[1
]}

Korot, Edward ^{[3
]}

Muscat, Stephanie ^{[4
]}

Palanker, Daniel A. ^{[2
]}

Williams, George A. ^{[1
,3
]}

机构：

[1] Associated Retinal Consultants, Royal Oak, MI USA

[2] Stanford Univ, Dept Ophthalmol, Hansen Expt Phys Lab, Stanford, CA 94305 USA

[3] Oakland Univ, William Beaumont Sch Med, Rochester, MI 48063 USA

[4] Stanford Univ, Stanford, CA 94305 USA

来源：

RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES | 2019年 / 39卷 / 05期

关键词：

innovation; stem cells; optogenetics; gene therapy; CRISPR; gene editing; retinal prosthetics; future; biotechnology; LEBER CONGENITAL AMAUROSIS; RESTORES VISUAL RESPONSES; ECTOPIC EXPRESSION; RPE65; MUTATIONS; INTRAVITREAL INJECTION; MICROBIAL RHODOPSINS; MICE; TRANSPLANTATION; RESTORATION; REPAIR;

D O I：

10.1097/IAE.0000000000002449

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: To review and discuss current innovations and future implications of promising biotechnology and biomedical offerings in the field of retina. We focus on therapies that have already emerged as clinical offerings or are poised to do so. Methods: Literature review and commentary focusing on stem cell therapies, gene-based therapies, optogenetic therapies, and retinal prosthetic devices. Results: The technologies discussed herein are some of the more recent promising biotechnology and biomedical developments within the field of retina. Retinal prosthetic devices and gene-based therapies both have an FDA-approved product for ophthalmology, and many other offerings (including optogenetics) are in the pipeline. Stem cell therapies offer personalized medicine through novel regenerative mechanisms but entail complex ethical and reimbursement challenges. Conclusion: Stem cell therapies, gene-based therapies, optogenetics, and retinal prosthetic devices represent a new era of biotechnological and biomedical progress. These bring new ethical, regulatory, care delivery, and reimbursement challenges. By addressing these issues proactively, we may accelerate delivery of care to patients in a safe, efficient, and value-based manner.

引用

页码：820 / 835

页数：16

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