(2E,2′E)-2,2′-(1,2,4-Thiadiazole-3,5-diyl)bis[3-arylacrylonitriles]: Synthesis and Antidote Activity Towards 2,4-D Herbicide

被引：2
|
作者：
Dakhno, P. G. [1 ]
Dotsenko, V. V. [1 ,2 ]
Strelkov, V. D. [1 ,2 ]
Vasilin, V. K. [3 ]
Aksenov, N. A. [2 ]
Aksenova, I. V. [2 ]
机构：
[1] Kuban State Univ, Krasnodar 350040, Russia
[2] North Caucasus Fed Univ, Stavropol 355009, Russia
[3] Kuban State Technol Univ, Krasnodar 350072, Russia
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2022年 / 92卷 / 12期
关键词：
cyanothioacetamide; 2-cyanothioacrylamides; diethyl sulfoxide; oxidative dimerization of thioamides; 1; 2; 4-thiadiazoles; herbicide antidotes; 3,5-DISUBSTITUTED 1,2,4-THIADIAZOLES; THIOAMIDES; CYANOTHIOACETAMIDE; CHOLINESTERASE; DERIVATIVES; CONVENIENT; INHIBITORS; OXIDATION; BLOCKERS; SYSTEM;
D O I：
10.1134/S1070363222120337
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Oxidation of (E)-3-aryl-2-cyanothioacrylamides under the action of the Et2S(O)-HCl system leads to the formation of (2E,2 ' E)-2,2 '-(1,2,4-thiadiazole-3,5-diyl)bis[3-arylacrylonitriles] in 54-91% yields. Structure of the obtained compounds was confirmed by the two-dimensional NMR spectroscopy data. A plausible reaction mechanism was discussed. Two compounds showed a pronounced antidote effect against 2,4-D herbicide in a laboratory experiment on sunflower seedlings in the absence of growth-stimulating activity.
引用
收藏
页码：2822 / 2831
页数：10
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