Multipotential Capacity of Human Adipose-derived Mesenchymal Stem Cells

被引：0
|
作者：
Guo, Bao-Feng [1 ]
Zhang, Ling [1 ]
Yin, Wei-Tian [1 ]
Ji, Kun [1 ]
Wei, Zhuang [1 ]
机构：
[1] Jilin Univ, Dept Surg, Prostate Dis Prevent & Treatment Res Ctr, China Japan Union Hosp,Norman Bethune Med Sch, Changchun, Peoples R China
来源：
2010 4TH INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICAL ENGINEERING (ICBBE 2010) | 2010年
基金：
中国国家自然科学基金;
关键词：
articular cartilage; adipose tissue; stem cell; chondrocyte; TISSUE; REGENERATION;
D O I：
暂无
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Adipose tissue is derived from the embryonic mesenchyme and can be isolated easily. The purpose of this study was to investigate the multipotent ability of adipose-derived mesenchymal stem cells and to investigate the molecular characterization of adipose-derived mesenchymal stem cells during chondrogenic differentiation in vitro. Our results showed that adipose- derived mesenchymal stem cells have the ability to differentiate into adipogenic, osteogenic, and chondrogenic cells with adipogenic, osteogenic, and chondrogenic medium in vitro. The expression of chondrogenic related molecules were detected by RT-PCR analysis during chondrogenic differentiation. These studies demonstrate that human adipose- derived mesenchymal stem cells have the multipotentiality and adipose tissue may represent a novel approach to form tissue engineering cartilage to heal the damage cartilage.
引用
收藏
页数：3
相关论文
共 50 条
  • [31] High efficient isolation and systematic identification of human adipose-derived mesenchymal stem cells
    Yang, Xu-Fang
    He, Xu
    He, Jian
    Zhang, Li-Hong
    Su, Xue-Jin
    Dong, Zhi-Yong
    Xu, Yun-Jian
    Li, Yan
    Li, Yu-Lin
    JOURNAL OF BIOMEDICAL SCIENCE, 2011, 18
  • [32] Angiogenic Activity of Human Adipose-Derived Mesenchymal Stem Cells Under Simulated Microgravity
    Ratushnyy, Andrey
    Ezdakova, Maria
    Yakubets, Danila
    Buravkova, Ludmila
    STEM CELLS AND DEVELOPMENT, 2018, 27 (12) : 831 - 837
  • [33] Responses of human adipose-derived mesenchymal stem cells to chemical microenvironment of the intervertebral disc
    Liang, Chengzhen
    Li, Hao
    Tao, Yiqing
    Zhou, Xiaopeng
    Li, Fangcai
    Chen, Gang
    Chen, Qixin
    JOURNAL OF TRANSLATIONAL MEDICINE, 2012, 10
  • [34] Effects of Rehmannia glutinosa oligosaccharide on human adipose-derived mesenchymal stem cells in vitro
    Zhang, Yu
    Wang, Yuhong
    Wang, Lei
    Zhang, Yanqin
    Qin, Yihong
    Chen, Ting
    Han, Weidong
    Chen, Guanghui
    LIFE SCIENCES, 2012, 91 (25-26) : 1323 - 1327
  • [35] Therapeutic approach of adipose-derived mesenchymal stem cells in refractory peptic ulcer
    Saleh, Mahshid
    Sohrabpour, Amir Ali
    Mehrabi, Mohammad Reza
    Seyhoun, Iman
    Vaezi, Amir Abbas
    STEM CELL RESEARCH & THERAPY, 2021, 12 (01)
  • [36] Effects of Adipose-Derived Mesenchymal Stem Cells and Human Amniotic Membrane on Sciatic Nerve Repair in Rats
    Xaki, Siyawash
    Fathi, Afshin
    Ariana, Mehdi
    Aghayan, Hamid Reza
    Arjmand, Babak
    Alavi-Moghadam, Sepideh
    Azhdari, Kamyar
    Hazrati, Ebrahim
    Zoshk, Mojtaba Yousefi
    ARCHIVES OF NEUROSCIENCE, 2021, 8 (03)
  • [37] Retinal Lineage Therapeutic Specific Effect of Human Orbital and Abdominal Adipose-Derived Mesenchymal Stem Cells
    Krief, Bryan
    Algor, Shira Weisthal
    Nakdimon, Itay
    Elhikis, Ayala
    Benhamou, Moshe
    Kadmon, Anouk Savir
    Keren, Shay
    Ohana, Oded
    Feldman, Ilan
    Ben Cnaan, Ran
    Leibovitch, Igal
    Loewenstein, Anat
    Barak, Adiel
    Barzelay, Aya
    STEM CELLS INTERNATIONAL, 2021, 2021
  • [38] The responses of human adipose-derived mesenchymal stem cells on polycaprolactone-based scaffolds: an in vitro study
    Osathanon, Thanaphum
    Chuenjitkuntaworn, Boontharika
    Nowwarote, Nunthawan
    Supaphol, Pitt
    Sastravaha, Panunn
    Subbalekha, Keskunya
    Pavasant, Prasit
    TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2014, 11 (03) : 239 - 246
  • [39] Human adipose-derived mesenchymal stem cells in vitro: evaluation of an optimal expansion medium preserving stemness
    Baer, Patrick C.
    Griesche, Nadine
    Luttmann, Werner
    Schubert, Ralf
    Luttmann, Arlette
    Geiger, Helmut
    CYTOTHERAPY, 2010, 12 (01) : 96 - 106
  • [40] Human and feline adipose-derived mesenchymal stem cells have comparable phenotype, immunomodulatory functions, and transcriptome
    Clark, Kaitlin C.
    Fierro, Fernando A.
    Ko, Emily Mills
    Walker, Naomi J.
    Arzi, Boaz
    Tepper, Clifford G.
    Dahlenburg, Heather
    Cicchetto, Andrew
    Kol, Amir
    Marsh, Lyndsey
    Murphy, William J.
    Fazel, Nasim
    Borjesson, Dori L.
    STEM CELL RESEARCH & THERAPY, 2017, 8
12345