Expression of IL-1β in supraspinal brain regions in rats with neuropathic pain

被引：90
作者：
Apkarian, A. Vania
Lavarello, Simona
Randolf, Anke
Berra, Hector H.
Chialvo, Dante R.
Besedovsky, Hugo O.
del Rey, Adriana
机构：
[1] Northwestern Univ, Feinberg Sch Med, Dept Physiol, Chicago, IL 60611 USA
[2] Univ Marburg, Inst Normal & Pathol Physiol, D-35032 Marburg, Germany
来源：
NEUROSCIENCE LETTERS | 2006年 / 407卷 / 02期
关键词：
cytokines; chronic pain; brainstem; thalamus; prefrontal cortex;
D O I：
10.1016/j.neulet.2006.08.034
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We examined mRNA expression of the pro-inflammatory cytokine IL-1 beta in the brainstem, thalamus, and prefrontal cortex in two rat models of neuropathic pain. Rats received a neuropathic injury: spared nerve injury (SNI) or chronic constriction injury (CCI), sham injury, or were minimally handled (control). Neuropathic pain-like behavior was monitored by tracking tactile thresholds. SNI-injured animals showed a robust decrease in tactile thresholds of the injured foot, while CCI-injured animals did not show tactile threshold changes. Ten or 24 days after nerve injury, IL-1 beta gene expression in the brain was determined by RT-PCR. IL-1 beta expression changes were observed mainly at 10 days after injury in the SNI animals, contralateral to the injury side, with increased expression in the brainstem and prefrontal cortex. The results indicate that neuro-immune activation in neuropathic pain conditions includes supraspinal brain regions, suggesting cytokine modulation of supraspinal circuitry of pain in neuropathic conditions. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：176 / 181
页数：6
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