Comparison of the efficacy of metagenomic next-generation sequencing and Xpert MTB/RIF in the diagnosis of tuberculous meningitis

被引：24
作者：
Yu, Guocan [1 ]
Wang, Xiaodan [2 ]
Zhu, Pengfei [1 ]
Shen, Yanqin [1 ]
Zhao, Wuchen [1 ]
Zhou, Lihong [1 ]
机构：
[1] Zhejiang Chinese Med & Western Med Integrated Hos, Zhejiang TB Diag & Treatment Ctr, Hangzhou, Zhejiang, Peoples R China
[2] Hangzhou Xihu Dist Integrated Chinese & Western M, Gen Med, Hangzhou, Zhejiang, Peoples R China
来源：
JOURNAL OF MICROBIOLOGICAL METHODS | 2021年 / 180卷
关键词：
Mycobacterium tuberculosis; mNGS; Xpert MTB/RIF; Tuberculous meningitis; CEREBROSPINAL-FLUID;
D O I：
10.1016/j.mimet.2020.106124
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Metagenomic next-generation sequencing (mNGS) is an emerging sequence-based method that detects genomic information of pathogenic microorganisms from a wide range of clinical specimens. The mNGS has moderate sensitivity and very high specificity for tuberculous meningitis, and the validity of mNGS was higher than that of Xpert MTB/RIF.
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