Comparison of the efficacy of metagenomic next-generation sequencing and Xpert MTB/RIF in the diagnosis of tuberculous meningitis

被引：35

作者：

Yu, Guocan ^{[1
]}

Wang, Xiaodan ^{[2
]}

Zhu, Pengfei ^{[1
]}

Shen, Yanqin ^{[1
]}

Zhao, Wuchen ^{[1
]}

Zhou, Lihong ^{[1
]}

机构：

[1] Zhejiang Chinese Med & Western Med Integrated Hos, Zhejiang TB Diag & Treatment Ctr, Hangzhou, Zhejiang, Peoples R China

[2] Hangzhou Xihu Dist Integrated Chinese & Western M, Gen Med, Hangzhou, Zhejiang, Peoples R China

来源：

JOURNAL OF MICROBIOLOGICAL METHODS | 2021年 / 180卷

关键词：

Mycobacterium tuberculosis; mNGS; Xpert MTB/RIF; Tuberculous meningitis; CEREBROSPINAL-FLUID;

D O I：

10.1016/j.mimet.2020.106124

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Metagenomic next-generation sequencing (mNGS) is an emerging sequence-based method that detects genomic information of pathogenic microorganisms from a wide range of clinical specimens. The mNGS has moderate sensitivity and very high specificity for tuberculous meningitis, and the validity of mNGS was higher than that of Xpert MTB/RIF.

引用

页数：3

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