Astrocytes and Glioblastoma cells release exosomes carrying mtDNA

被引：535

作者：

Guescini, Michele ^{[2
]}

Genedani, Susanna ^{[1
]}

Stocchi, Vilberto ^{[2
]}

Agnati, Luigi Francesco ^{[1
,3
]}

机构：

[1] Univ Modena & Reggio Emilia, Dept Biomed Sci, I-41100 Modena, Italy

[2] Univ Urbino Carlo Bo, Dept Biomol Sci, Urbino, Italy

[3] IRCCS Lido, Venice, Italy

来源：

JOURNAL OF NEURAL TRANSMISSION | 2010年 / 117卷 / 01期

关键词：

Glioblastoma cells; Astrocytes; Mitochondrial DNA; Exosomes; Intercellular communication; PROTEINS; DISEASE; TRANSPORT; NANOTUBES; PEPTIDES; PROVIDE;

D O I：

10.1007/s00702-009-0288-8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cells can exchange information not only by means of chemical and/or electrical signals, but also via microvesicles released into the intercellular space. The present paper, for the first time, provides evidence that Glioblastoma and Astrocyte cells release microvesicles, which carry mitochondrial DNA (mtDNA). These microvesicles have been characterised as exosomes in view of the presence of some protein markers of exosomes, such as Tsg101, CD9 and Alix. Thus, the important finding has been obtained that bonafide exosomes, constitutively released by Glioblastoma cells and Astrocytes, can carry mtDNA, which can be, therefore, transferred between cells. This datum may help the understanding of some diseases due to mitochondrial alterations.

引用

页码：1 / 4

页数：4

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