Effect of preconceptional metformin on abortion risk in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials

被引：79
作者：
Palomba, Stefano [1 ]
Falbo, Angela [1 ]
Orio, Francesco, Jr. [2 ]
Zullo, Fulvio [1 ]
机构：
[1] Magna Graecia Univ Catanzaro, Dept Gynecol & Obstet, I-88100 Catanzaro, Italy
[2] Univ Parthenope, Fac Exercise Sci, Naples, Italy
来源：
FERTILITY AND STERILITY | 2009年 / 92卷 / 05期
关键词：
Abortion; metformin; miscarriage; polycystic ovary syndrome; treatment; IN-VITRO FERTILIZATION; FACTOR-BINDING PROTEIN-1; INSULIN-RESISTANT WOMEN; EARLY-PREGNANCY LOSS; NORMAL-WEIGHT WOMEN; CLOMIPHENE CITRATE; DOUBLE-BLIND; INDUCED OVULATION; LUTEINIZING-HORMONE; METABOLIC PROFILES;
D O I：
10.1016/j.fertnstert.2008.08.087
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective: To evaluate the effect of pregestational metformin administration on abortion risk in polycystic ovary syndrome (PCOS) patients. Design: Systematic review and meta-analysis. Setting: Academic Department of Obstetrics and Gynecology in Italy. Patient(s): Women affected by PCOS receiving pregestational metformin. Intervention(s): Systematic review of randomized controlled trials (RCTs) published up to June 2008 and subsequent meta-analysis. Main Outcome Measure(s): Abortion rate. Result(s): Seventeen RCTs were included in the final analysis. Overall, no effect of the metformin administration was detected on the abortion risk. No statistically significant effect of metformin on the abortion risk was observed in any comparison when subgrouping the RCTs according to received treatment. Conclusion(s): Metformin has no effect on the abortion risk in PCOS patients when administered before pregnancy. (Fertil Steril (R) 2009;92:1646-58. (C) 2009 by American Society for Reproductive Medicine.)
引用
收藏
页码：1646 / 1658
页数：13
相关论文
共 79 条
[11]  
COYRALCASTEL S, J NEUROENDOCRINOL
[12]   Effects of metformin on gonadotropin-induced ovulation in women with polycystic ovary syndrome [J].
De Leo, V ;
la Marca, A ;
Ditto, A ;
Morgante, G ;
Cianci, A .
FERTILITY AND STERILITY, 1999, 72 (02) :282-285
[13]   Increased levels of serum advanced glycation end-products in women with polycystic ovary syndrome [J].
Diamanti-Kandarakis, E ;
Piperi, C ;
Kalofoutis, A ;
Creatsas, G .
CLINICAL ENDOCRINOLOGY, 2005, 62 (01) :37-43
[14]   AMP kinase activation increases glucose uptake, decreases apoptosis, and improves pregnancy outcome in embryos exposed to high IGF-I concentrations [J].
Eng, Grace S. ;
Sheridan, Rachael A. ;
Wyman, Amanda ;
Chi, Maggie M. -Y. ;
Bibee, Kristin P. ;
Jungheim, Emily S. ;
Moley, Kelle H. .
DIABETES, 2007, 56 (09) :2228-2234
[15]   Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS) [J].
Fauser, BCJM ;
Chang, J ;
Azziz, R ;
Legro, R ;
Dewailly, D ;
Franks, S ;
Tarlatzis, BC ;
Fauser, B ;
Balen, A ;
Bouchard, P ;
Dahlgren, E ;
Devoto, L ;
Diamanti, E ;
Dunaif, A ;
Filicori, M ;
Homburg, R ;
Ibanez, L ;
Laven, J ;
Magoffin, D ;
Nestler, J ;
Norman, RJ ;
Pasquali, R ;
Pugeat, M ;
Strauss, J ;
Tan, S ;
Taylor, A ;
Wild, R ;
Wild, S ;
Ehrmann, D ;
Lobo, R .
HUMAN REPRODUCTION, 2004, 19 (01) :41-47
[16]   The effect of metformin on ovarian stimulation and in vitro fertilization in insulin-resistant women with polycystic ovary syndrome:: an open-label randomized cross-over trial [J].
Fedorcsák, P ;
Dale, PO ;
Storeng, R ;
Åbyholm, T ;
Tanbo, T .
GYNECOLOGICAL ENDOCRINOLOGY, 2003, 17 (03) :207-214
[17]   Ovarian function and metabolic factors in women with oligomenorrhea treated with metformin in a randomized double blind placebo-controlled trial [J].
Fleming, R ;
Hopkinson, ZE ;
Wallace, AM ;
Greer, IA ;
Sattar, N .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (02) :569-574
[18]   Sequential treatment of metformin and clomiphene citrate in clomiphene-resistant women with polycystic ovary syndrome: a randomized, controlled trial [J].
George, SS ;
George, K ;
Irwin, C ;
Job, V ;
Selvakumar, R ;
Jeyaseelan, V ;
Seshadri, MS .
HUMAN REPRODUCTION, 2003, 18 (02) :299-304
[19]   Metformin therapy throughout pregnancy reduces the development of gestational diabetes in women with polycystic ovary syndrome [J].
Glueck, CJ ;
Wang, P ;
Kobayashi, S ;
Phillips, H ;
Sieve-Smith, L .
FERTILITY AND STERILITY, 2002, 77 (03) :520-525
[20]   Continuing metformin throughout pregnancy in women with polycystic ovary syndrome appears to safely reduce first-trimester spontaneous abortion: a pilot study [J].
Glueck, CJ ;
Phillips, H ;
Cameron, D ;
Sieve-Smith, L ;
Wang, P .
FERTILITY AND STERILITY, 2001, 75 (01) :46-52
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