Effect of preconceptional metformin on abortion risk in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials

被引：79

作者：

Palomba, Stefano ^{[1
]}

Falbo, Angela ^{[1
]}

Orio, Francesco, Jr. ^{[2
]}

Zullo, Fulvio ^{[1
]}

机构：

[1] Magna Graecia Univ Catanzaro, Dept Gynecol & Obstet, I-88100 Catanzaro, Italy

[2] Univ Parthenope, Fac Exercise Sci, Naples, Italy

来源：

FERTILITY AND STERILITY | 2009年 / 92卷 / 05期

关键词：

Abortion; metformin; miscarriage; polycystic ovary syndrome; treatment; IN-VITRO FERTILIZATION; FACTOR-BINDING PROTEIN-1; INSULIN-RESISTANT WOMEN; EARLY-PREGNANCY LOSS; NORMAL-WEIGHT WOMEN; CLOMIPHENE CITRATE; DOUBLE-BLIND; INDUCED OVULATION; LUTEINIZING-HORMONE; METABOLIC PROFILES;

D O I：

10.1016/j.fertnstert.2008.08.087

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To evaluate the effect of pregestational metformin administration on abortion risk in polycystic ovary syndrome (PCOS) patients. Design: Systematic review and meta-analysis. Setting: Academic Department of Obstetrics and Gynecology in Italy. Patient(s): Women affected by PCOS receiving pregestational metformin. Intervention(s): Systematic review of randomized controlled trials (RCTs) published up to June 2008 and subsequent meta-analysis. Main Outcome Measure(s): Abortion rate. Result(s): Seventeen RCTs were included in the final analysis. Overall, no effect of the metformin administration was detected on the abortion risk. No statistically significant effect of metformin on the abortion risk was observed in any comparison when subgrouping the RCTs according to received treatment. Conclusion(s): Metformin has no effect on the abortion risk in PCOS patients when administered before pregnancy. (Fertil Steril (R) 2009;92:1646-58. (C) 2009 by American Society for Reproductive Medicine.)

引用

页码：1646 / 1658

页数：13

共 79 条

[1]

[Anonymous], MIDDLE E FERTIL SOC

[2] Nutrition and reproduction in women [J].

Baird, DT ;

Cnattingius, S ;

Collins, J ;

Evers, JLH ;

Glasier, A ;

Heitmann, BL ;

Norman, RJ ;

Ong, KK ;

Sunde, A ;

Cohen, J ;

Cometti, B ;

Crosignani, PG ;

Devroey, P ;

Diczfalusy, E ;

Diedrich, K ;

Fraser, L ;

Gianaroli, L ;

Liebaers, I ;

Mautone, G ;

Ragni, G ;

Tarlatzis, B ;

Van Steirteghem, A .

HUMAN REPRODUCTION UPDATE, 2006, 12 (03) :193-207

[3] MISCARRIAGE RATES FOLLOWING INVITRO FERTILIZATION ARE INCREASED IN WOMEN WITH POLYCYSTIC OVARIES AND REDUCED BY PITUITARY DESENSITIZATION WITH BUSERELIN [J].

BALEN, AH ;

TAN, SL ;

MACDOUGALL, J ;

JACOBS, HS .

HUMAN REPRODUCTION, 1993, 8 (06) :959-964

[4] A meta-analysis of pregnancy outcomes in women with polycystic ovary syndrome [J].

Boomsma, C. M. ;

Eijkemans, M. J. C. ;

Hughes, E. G. ;

Visser, G. H. A. ;

Fauser, B. C. J. M. ;

Macklon, N. S. .

HUMAN REPRODUCTION UPDATE, 2006, 12 (06) :673-683

[5] AN INFORMATIVE PROTOCOL FOR THE INVESTIGATION OF RECURRENT MISCARRIAGE - PRELIMINARY EXPERIENCE OF 500 CONSECUTIVE CASES [J].

CLIFFORD, K ;

RAI, R ;

WATSON, H ;

REGAN, L .

HUMAN REPRODUCTION, 1994, 9 (07) :1328-1332

[6]

*COCHR MENSTR DIS, 2005, TRIALS REG

[7] METFORMIN IN MANAGEMENT OF PREGNANT INSULIN-INDEPENDENT DIABETICS [J].

COETZEE, EJ ;

JACKSON, WPU .

DIABETOLOGIA, 1979, 16 (04) :241-245

[8]

COETZEE EJ, 1980, S AFR MED J, V58, P795

[9]

COETZEE EJ, 1984, S AFR MED J, V65, P635

[10] A systematic review of the reproductive system effects of metformin in patients with polycystic ovary syndrome [J].

Costello, MF ;

Eden, JA .

FERTILITY AND STERILITY, 2003, 79 (01) :1-13

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